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Peptide record

TPDB06004

Antibacterial Antifungal Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB06004
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb DRAMP dbAMP
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
WWVAARAARR
Physicochemical Analysis
C57H87N21O11
NDCEQGHILKMFPSTY
A
1242.45
12.70
3
0
7
+3
-1.88
-0.390
69.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
885.35
0
Residue Composition
number
4
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
10
C57H87N21O11
1242.45
12.70
+3
-1.88
-0.390
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
1810 µM
Hemolytic Cytotoxic
50% Hemolysis | 1810 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity. | Biopolymers | 2017
Evidence 2 Activity

Activity

HC50
Toxicity
1810 µM
Hemolytic
Hemolytic_activity: [Ref.28073163] HC50 = 1810 µM against human red blood cells. Note: HC50 is the half-maximal hemolytic concentration.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2017 May 108(3). doi: 10.1002/bip.23006.