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Peptide record

TPDB05987

(RG)5 Antibacterial Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB05987
(RG)5
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
RGRGRGRGRG
Physicochemical Analysis
C40H77N25O11
ANDCEQHILKMFPSTWYV
RG
1084.21
13.00
5
0
0
+5
4.10
-2.450
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C40H77N25O11
1084.21
13.00
+5
4.10
-2.450
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87, A549, B. End3 And C8-D1A Cells

Assay & Model

BALB/c nude mice
BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Paclitaxel(PTX) , Coumarin-6 labelled micelles
Cytoplasm
The strong fluorescence intensity observed with ((HE)5-RG)5-CPSO micelles at higher at pH 6.5 than at pH 7.4 all time points was attributed to the high cell-penetrating ability of the cationic peptide (RG)5.
LDL-mediated endocytosis
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC