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Peptide record

TPDB05956

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB05956
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIAKVALKAL
Physicochemical Analysis
C50H95N13O11
RNDCEQGHMFPSTWY
AK
1054.38
10.84
3
0
7
+3
1.10
1.000
176.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C50H95N13O11
1054.38
10.84
+3
1.10
1.000
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
23.6 ug/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resist
Evidence 2 Activity

Activity

MIC
Antibacterial
8.7 ug/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRS
Evidence 3 Activity

Activity

MIC
Antibacterial
14.4 ug/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

tivity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 4 Activity

Activity

MIC
Antibacterial
67.8 ug/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

IC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 5 Activity

Activity

MIC
Antifungal
23.6 ug/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resist
Evidence 6 Activity

Activity

MIC
Antifungal
8.7 ug/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRS
Evidence 7 Activity

Activity

MIC
Antifungal
14.4 ug/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

tivity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 8 Activity

Activity

MIC
Antifungal
67.8 ug/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

IC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 9 Activity

Activity

MIC
Antiparasitic
23.6 ug/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resist
Evidence 10 Activity

Activity

MIC
Antiparasitic
8.7 ug/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRS
Evidence 11 Activity

Activity

MIC
Antiparasitic
14.4 ug/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

tivity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 12 Activity

Activity

MIC
Antiparasitic
67.8 ug/mL

Target

Staphylococcus aureus MRSA

Source & Reference

DRAMP

Other

IC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 13 Activity

Activity

MIC
Antiviral
23.6 ug/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resist
Evidence 14 Activity

Activity

MIC
Antiviral
8.7 ug/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Activity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRS
Evidence 15 Activity

Activity

MIC
Antiviral
14.4 ug/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

tivity against E. coli ATCC 25922 (MIC 23.6 ug/mL), S. aureus ATCC 25923 (MIC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 16 Activity

Activity

MIC
Antiviral
67.8 ug/mL

Target

Staphylococcus aureus MRSA

Source & Reference

DRAMP

Other

IC 8.7 ug/mL), B. subtilis (MIC 14.4 ug/mL), and multidrug-resistant meticillin-resistant S. aureus MRSA (MIC 67.8 ug/mL).
Evidence 17 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis. | Int J Antimicrob Agents | 2011
Evidence 18 Activity

Activity

8% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis. | Int J Antimicrob Agents | 2011
Evidence 19 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 20 Activity

Activity

25% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
25% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 21 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22014884]3.15% hemolytic activity at 100 µg/mL, 7.95% hemolytic activity at 200 µg/mL against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2011 Dec 38(6):510-515.##J Biol Chem. 1991 Oct 15 266(29):19851-19857.