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Peptide record

TPDB05953

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB05953
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KLLKRIKTLL
Physicochemical Analysis
C58H112N16O12
ANDCEQGHMFPSWYV
L
1225.63
11.73
4
0
5
+4
1.37
0.280
195.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
3
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C58H112N16O12
1225.63
11.73
+4
1.37
0.280
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
24 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S-aureus ATCC 25923 (MIC >24 ug/ml) and E. coli ATCC 25922 (MIC 24 ug/ml). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
312 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 312 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of anoplin. | J Pept Sci | 2005