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Peptide record

TPDB05929

Antibacterial Antifungal Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB05929
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RKKRWWRRKK
Physicochemical Analysis
C70H118N28O11
ANDCEQGHILMFPSTYV
RK
1527.89
12.89
8
0
2
+8
3.50
-3.540
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
719.95
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C70H118N28O11
1527.89
12.89
+8
3.50
-3.540
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 12 uM), S. aureus (MIC>100 uM), P.aeruginosa (MIC > 100 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 12 uM), S. aureus (MIC>100 uM), P.aeruginosa (MIC > 100 uM)
Evidence 3 Activity

Activity

MIC
Antifungal
12 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 12 uM), S. aureus (MIC>100 uM), P.aeruginosa (MIC > 100 uM)
Evidence 4 Activity

Activity

MIC
Antifungal
>100 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E. coli (MIC 12 uM), S. aureus (MIC>100 uM), P.aeruginosa (MIC > 100 uM)
Evidence 5 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility | Biotechnol Bioeng | 2014
Evidence 6 Activity

Activity

7% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
7% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility | Biotechnol Bioeng | 2014
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
6.5 %
Hemolytic
Hemolytic_activity: [Ref.23860860] 6.5% hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Microbiol. 2012 2012:764834. ##Biotechnol Bioeng. 2014 Jan 111(1):37-49. doi: 10.1002/bit.25003.