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Peptide record

TPDB05924

Antibacterial Antifungal Hemolysis Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05924
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KWRRWVRWI
Physicochemical Analysis
C68H100N22O10
ANDCEQGHLMFPSTY
RW
1385.68
12.71
4
0
5
+4
-2.37
-1.267
75.56
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
1190.75
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
9
C68H100N22O10
1385.68
12.71
+4
-2.37
-1.267
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
The recombinat form is more active against E. coli (MIC 2 uM) and S. aureus (MIC 4 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

The recombinat form is more active against E. coli (MIC 2 uM) and S. aureus (MIC 4 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
The recombinat form is more active against E. coli (MIC 2 uM) and S. aureus (MIC 4 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb

Other

The recombinat form is more active against E. coli (MIC 2 uM) and S. aureus (MIC 4 uM).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms. | Biochem Biophys Res Commun | 2010
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhancement of Antibacterial Activity of Short Tryptophan-rich Antimicrobial Peptide Pac-525 by Replacing Trp with His(chx) | Bull Korean Chem Soc | 2014
Evidence 7 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.