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Peptide record

TPDB05923

Antibacterial Anticancer Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05923
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RWRWWWRWR
Physicochemical Analysis
C79H100N26O10
ANDCEQGHILKMFPSTYV
W
1573.83
12.88
4
0
5
+4
-6.01
-2.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
1747.33
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
9
C79H100N26O10
1573.83
12.88
+4
-6.01
-2.500
Evidence Records 3 records
Evidence 1 Activity

Activity

10% hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. | J Med Chem | 2018
Evidence 2 Activity

Activity

10% Killing
Toxicity
64 µM
Cytotoxic
10% Killing | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides. | J Med Chem | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Synthetic peptides that form nanostructured micelles have potent antibiotic and antibiofilm activity against polymicrobial infections. | Proc Natl Acad Sci U S A | 2023