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Peptide record

TPDB05899

Cr-ACP1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05899
Cr-ACP1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF pep-lab CAFPdb ToxinPred 3.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AWKLFDDGV
Physicochemical Analysis
C50H71N11O14
RNCEQHIMPSTY
D
1050.18
3.88
1
2
5
-1
-0.18
0.044
86.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
523.72
0
Residue Composition
number
1
A
0
R
0
N
2
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
9
C50H71N11O14
1050.18
3.88
-1
-0.18
0.044
Free
L
Not Available
Free
Antibacterial
Seeds,Cycas revoluta
Evidence Records 4 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
5% Hemolysis | 1000 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. | J Cell Biochem | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
>4000 µM
Cytotoxic
IC50 | >4000 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. | J Cell Biochem | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
1.5 mM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.21882228] Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100). Cr-ACP1 induced hemolysis of 7% at the conentration of 1 mM. | Cytotoxicity: [Ref.21882228] IC50 = 1.5 mM in Hep2 (Human epidermoid cancer cells) IC50 = 0.9 mM in HCT15 (human colon carcinoma cells HCT15) Cr-ACP1 induced a cell viability of 66% at the concentration of 4 mM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Cell Biochem. 2012 Jan 113(1):184-193.