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Peptide record

TPDB05891

Antibacterial Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05891
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGLLGSLL
Physicochemical Analysis
C46H77N9O11
ARNDCEQHIKMPTWYV
L
932.17
6.02
0
0
6
-0
-3.78
2.244
216.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
5
L
0
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C46H77N9O11
932.17
6.02
-0
-3.78
2.244
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
34 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 34 uM), but not Gram-negative bacteria or yeast.
Evidence 2 Activity

Activity

MIC
Antifungal
34 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 34 uM), but not Gram-negative bacteria or yeast.
Evidence 3 Activity

Activity

100% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
100% Hemolysis | >250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3. | Chem Biol Drug Des | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
100 %
Hemolytic
Hemolytic_activity: [Ref.25056849] 100% hemolysis at 80 mg/L against horse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2015 Mar 85(3):259-67. doi: 10.1111/cbdd.12396.