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Peptide record

TPDB05883

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

9 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05883

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP Peptipedia CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

TPFKLSLHL

FASTA

>TPDB05883|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=9
TPFKLSLHL

Formula C51H82N12O12

Absent Amino Acids ARNDCEQGIMWYV

Common Amino Acids L

Mass 1055.29

PI 10.10

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index -0.14

Hydrophobicity 0.444

Aliphatic Index 130.00

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 3 K: 1 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C51H82N12O12

Mass

1055.29

10.10

Net Charge

Boman Index

-0.14

Hydrophobicity

0.444

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6535

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism S. saprophyticus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis CCT 2471

Source & Reference

Database Source dbAMP

Other

Evidence Text

against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E. cloacae ACCT 23355 (MIC 15 ug/ml), K

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli CCT 1371

Source & Reference

Database Source dbAMP

Other

Evidence Text

l), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E. cloacae ACCT 23355 (MIC 15 ug/ml), K. pneumoniae ACCT 13883 (MIC 15 ug/ml), P. aerugi

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Enterobacter cloacae ACCT 23355

Source & Reference

Database Source dbAMP

Other

Evidence Text

l), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E. cloacae ACCT 23355 (MIC 15 ug/ml), K. pneumoniae ACCT 13883 (MIC 15 ug/ml), P. aeruginsa ACCT 27853 (MIC 15 ug/ml), and yea

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Klebsiella pneumoniae ACCT 13883

Source & Reference

Database Source dbAMP

Other

Evidence Text

), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E. cloacae ACCT 23355 (MIC 15 ug/ml), K. pneumoniae ACCT 13883 (MIC 15 ug/ml), P. aeruginsa ACCT 27853 (MIC 15 ug/ml), and yeast C. albicans (MIC 2.5 ug/ml). Jelleines

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism P. aeruginsa ACCT 27853

Source & Reference

Database Source dbAMP

Other

Evidence Text

15 ug/ml), E. cloacae ACCT 23355 (MIC 15 ug/ml), K. pneumoniae ACCT 13883 (MIC 15 ug/ml), P. aeruginsa ACCT 27853 (MIC 15 ug/ml), and yeast C. albicans (MIC 2.5 ug/ml). Jelleines are produced constitutively by the work

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

. pneumoniae ACCT 13883 (MIC 15 ug/ml), P. aeruginsa ACCT 27853 (MIC 15 ug/ml), and yeast C. albicans (MIC 2.5 ug/ml). Jelleines are produced constitutively by the workers and secreted into Royal Jelly. Comp

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6535

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism S. saprophyticus

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis CCT 2471

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli CCT 1371

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Enterobacter cloacae ACCT 23355

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Klebsiella pneumoniae ACCT 13883

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism P. aeruginsa ACCT 27853

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6535

Source & Reference

Database Source NA

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E.

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism S. saprophyticus

Source & Reference

Database Source NA

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E.

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis CCT 2471

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli CCT 1371

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Enterobacter cloacae ACCT 23355

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Klebsiella pneumoniae ACCT 13883

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism P. aeruginsa ACCT 27853

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6535

Source & Reference

Database Source NA

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E.

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 10 µg/mL

Target

Target Organism S. saprophyticus

Source & Reference

Database Source NA

Other

Evidence Text

Active against G+ bacteria S. aureus ATCC 6535 (MIC 15 ug/ml), S. saprophyticus (MIC 10 ug/ml), B. subtilis CCT 2471 (MIC 30 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 15 ug/ml), E.

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis CCT 2471

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli CCT 1371

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism Enterobacter cloacae ACCT 23355

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism Klebsiella pneumoniae ACCT 13883

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism P. aeruginsa ACCT 27853

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text