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Peptide record

TPDB05875

DA Antibacterial Anticancer Antifungal Antiparasitic Toxicity Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05875
DA
Antibacterial Anticancer Antifungal Antiparasitic Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP dbAMP 3.0 i2APP TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
C-terminal: amide group (-NH2)
Sequence
RLYLRIGRR
Physicochemical Analysis
C53H95N21O11
ANDCEQHKMFPSTWV
R
1202.47
12.40
4
0
4
+4
0.88
-0.844
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
123.91
1
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C53H95N21O11
1202.47
12.40
+4
0.88
-0.844
amide group (-NH2)
RGD
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

endothelial cell
Targeting
integrin αVβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Anti-angiogenesis activities of novel peptide complexes: mitochondria-disruptive 9mer peptides conjugated with the integrin alpha V beta 3-homing cyclic RGD motif
2012
Takashi Iwasaki et al. Biosci Biotechnol Biochem. 2012 76(11):2044-8.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Cos-1 African green monkey kidney cancer (Riken Cell Bank, RCB0143), HepG2 human liver cancer (RCB1886), NIH-3T3 mouse fibroblastic (RCB2767) cell line,RERF-LC-AI human carcinoma (RCB0444) cell line, Human umbilical vein endothelial cells (HUVECs)
Synthetic
cyclic RGD peptide
Additional Detail Fields 2 fields
cyclic RGD peptide
Cos-1 African green monkey kidney cancer (Riken Cell Bank, RCB0143), HepG2 human liver cancer (RCB1886), NIH-3T3 mouse fibroblastic (RCB2767) cell line,RERF-LC-AI human carcinoma (RCB0444) cell line, Human umbilical vein endothelial cells (HUVECs)