Peptide record

TPDB05861

9xArginine (9R) ARG ARG (R9) Arg8 Arg9 EXO-R9-G3139 Non-stapled R9 Nona-arginine nonaarginine (R9) Oligoarginine R9 (conjugate 1b) R9 peptide R9-HuscFv27 (Transbodies) R9-HuscFv43 (Transbodies) R9-HuscFv49 (Transbodies) Stapled peptide R9 EGFP-9R F7 R9 SR9 XIAP-9R Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard

9 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05861

Peptide_Name

Activity

Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

RRRRRRRRR

FASTA

>TPDB05861|Antibacterial;Antifungal;Antiviral;Blood-Brain Barrier;Cell-penetrating Peptides|length=9
RRRRRRRRR

Formula C54H110N36O10

Absent Amino Acids ANDCEQGHILKMFPSTWYV

Common Amino Acids R

Mass 1423.70

PI 13.30

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +9

Boman Index 7.29

Hydrophobicity -4.500

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C54H110N36O10

Mass

1423.70

13.30

Net Charge

Boman Index

7.29

Hydrophobicity

-4.500

C_terminal_Modification

Free

Chirality

Ionic_State

Cationic

Linearity

Linear Cyclic

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CS)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)O N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Nucleic acid (pDNA)

Subcellular Localization Cytosol

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Standard and Annexin 2-GFP transfected MDCK cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Nanoparticle (PMS labelled with the fluorescent probe di-4-ANEPPDHQ)

Uptake Efficiency More efficient in provoking bud formation

Uptake Mechanism Endocytosis, direct translocation or physical endocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line U87MG cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Fluorophore (FITC)

Uptake Efficiency Higher than peptide 1

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 4 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line C166-eGFP cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Patent WO 2011/020188 A1

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Nucleic acid (siRNA)

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 5 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type FAM-labelled

Subcellular Localization Cytosol

Uptake Efficiency ARG a 2-fold increase in permeability efficiency over RWRWR

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 6 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Rat Primary Cortical Cultures

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 7 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Rat Primary Cortical Cultures

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Uptake Mechanism Heparan sulfate receptor-mediated endocytic pathway

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 8 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, Hct116, Nih3T3, And Hacat Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type FITC-siVEGF

Uptake Efficiency BR2-siRNA-delivery efficiency was 2-fold higher than that of R9

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 9 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek 293, HeLa, Skov3, And Nci-H460 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type pDNA(GFP)

Subcellular Localization Cytoplasm

Uptake Efficiency B-mR9/pDNA polyplex had high transfection efficiency compared to the conventional linear R9 and mR9 CPP.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 10 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa And Opm-2 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type FAM-labelled

Subcellular Localization Cytoplasm

Uptake Efficiency TAT and ARG demonstrated higher permeability efficiencies compared to OWRWR and RWRWR

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 11 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line BY-2 Cells, A. thaliana Cotyledons, And O. Sativa Calli

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Subcellular Localization Cytosol

Uptake Efficiency The efficiency of dTat-Sar-EED4 was up to ∼20-fold higher than dTat , R9 and BP100

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 12 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, A549, Jurkat And CHO-K1 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Plasmid DNA (pDNA)

Subcellular Localization Cytosol

Uptake Efficiency Peptide 3 was 2.5 to 17 times higher than that of R9

Uptake Mechanism Macropinocytosis and clathrin mediated endocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 13 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ev71 Infected-Rd Cells, , CHO-K1 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type HuscFv27 antibody

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCSGGGSSCC

Evidence 14 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ev71 Infected-Rd Cells, , CHO-K1 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type HuscFv43 antibody

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 15 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ev71 Infected-Rd Cells, , CHO-K1 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type HuscFv49 antibody

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 16 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Dc2.4 Dcs , Splenocytes From C57Bl/6 Mice

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type FITC-dye and gp100 peptide to the N terminus

Subcellular Localization Cytosol

Uptake Mechanism Endocytosis

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCC

Evidence 17 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line RAW264.7 Cells

Assay & Model

In Vitro Model 7−8-week-old male C57/6J mice

In Vivo Model 7−8-week-old male C57/6J mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Cy5 and Triangular DNA origami nanostructures (tDONs)

Uptake Efficiency tDONs-R9 showed a higher cellular uptake by macrophages than ssDNA and tDONs.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCTHHHHHHHHTTCCC

Evidence 18 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line ARPE-19, J774A.1 Cells

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type SOCS3-KIR

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCCC

Evidence 19 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293 Cells, Rat Cardiomyocytes

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Cargo(1–9): IEKELAQQY , Cargo(8–18): QYQNADAITLE, Cargo(1–11): IEKELAQQYQN

Subcellular Localization Cytosol

Uptake Efficiency Arg9 also slowed Ca2+ uptake, albeit to a lesser extent than Arg11,

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCGGGTSCC

Evidence 20 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293 Cells ,Mesc-Derived Cells , Human Newborn Fibroblasts, And CHO Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Red fluorescent proteins (dsRED)

Subcellular Localization Cytoplasm

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCSSCCCC

Evidence 21 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Bsr Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type P16 and its derivatives

Uptake Efficiency

Both P16 and the derivative P16b6 could inhibit the replication of RABV with dosage effect suggesting that the CPP was efcient in intracellular delivery of antiviral peptides.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSCCCCCSSCCCC

Evidence 22 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Mia Paca-2, Panc-1, Upn3, Capan-1, And Bxpc-3

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type caPeptide

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCC

Evidence 23 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Mouse Embryo Fibroblasts (Mefs) And A549 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type C1 sequence and carboxyfluorescein (FAM) dye

Subcellular Localization Cytosol and Nuclei

Uptake Efficiency

The fluorescent images at less than or equal to 5 microM peptides show that the peptide can access the cell interior at a variety of concentrations and within 2 h of dosing.

Uptake Mechanism Endosomal uptake

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 24 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Skov-3 And HeLa Cells

Assay & Model

In Vitro Model 8 week-old female BALB/c mice

In Vivo Model 8 week-old female BALB/c mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type FITC-labeled Mn:ZnS Nanoparticels loaded with Paclitaxel (PTX)

Uptake Efficiency

Intracellular fluorescence was improved with R9-modified NPs compared to the PEN and pVEC which was confirmed by flow cytometry

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSSCGGGHHHHSCCC

Evidence 25 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Huh7 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Monoclonal HuscFvs

Subcellular Localization Cytoplasm

Uptake Efficiency

Co-localization of the R9-HuscFv99 and the native NS5A, which appeared in yellow/orange after merging at different levels of the cell sections, are seen.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCCCCCC

Evidence 26 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hepg2, Cos-7 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type HuscFvs

Subcellular Localization Cytoplasm

Uptake Efficiency The R9-HuscFvs of all clones were found to be cell penetrable, and they were located predominantly in the cytoplasm.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 27 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Wheat Microspores

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Cys-mCherry protein

Subcellular Localization Cytoplasm and nucleus

Uptake Efficiency R9-Cys-mCherry protein displayed the highest uptake

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCSCTTSSSSCCCCCC

Evidence 28 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line SyneCHOcystis Sp. Pcc 6803, Escherichia Coli Dh5A, Arthrobacter Ilicis D-50, Thermus Aquaticus

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type GFP attached

Uptake Efficiency R9/GFP complexes can be taken up by cells

Uptake Mechanism Lipid raft-dependent micropinocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCCCCCC

Evidence 29 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line SyneCHOcystis Sp. Pcc 6803, Escherichia Coli Dh5A, Arthrobacter Ilicis D-50, Thermus Aquaticus

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Carboxyl-functionalized CdSe/ZnS QDs

Uptake Efficiency Strong fluorescent signal was detected in cells treated with SR9/QD complexes.

Uptake Mechanism Macropinocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSSCCCC

Evidence 30 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Carboxyl-functionalized CdSe/ZnS QDs eFluor 625NC (red luminescent QD)

Subcellular Localization Early Endosomes

Uptake Efficiency Transduction lower than HR9

In Vitro or In Vivo In vitro

DSSP Secondary Structure CTTTTTCCC

Evidence 31 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293 Cells

Assay & Model

In Vitro Model Hartley guinea pig cochleae

In Vivo Model Hartley guinea pig cochleae

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Enhanced green fluorescent protein (EGFP)

Subcellular Localization Cytoplasm And Into Some Of The Nuclei

Uptake Efficiency GFP intensity with EGFP-9R was higher than that in EGFP-treated cells

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSCCSCCCSSSSCCCSTTTCSTTTSCCC

Evidence 32 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293 Cells

Assay & Model

In Vitro Model Hartley guinea pigs

In Vivo Model Hartley guinea pigs

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Chimeric

Cargo Type X-linked inhibitor of apoptosis protein (XIAP)

Subcellular Localization Cytoplasm And Into Some Of The Nuclei

Uptake Efficiency Transduction level in the s-XIAP-9R Group increased

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCSCCCCCCCCSCSCHHHHHHHSCSSSCCSCCSSSSCC

Evidence 33 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line MCF-7

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Silver nanoparticles (AgNPs)

Subcellular Localization Mitochondria

Uptake Efficiency Enhance uptake of AgNP

Uptake Mechanism Phagocytosis or passive nonspecific diffusion

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCC

Evidence 34 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, Nih 3T3 And A549 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Fluorescein isothiocyanate (FITC), rhodamine B (Rho), or naphthofluorescein (NF)-labelled

Subcellular Localization Cytoplasm

Uptake Efficiency Tat and R9 were ~2-fold less efficiently than cFΦR4

In Vitro or In Vivo In vitro

Evidence 35 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human Endothelial Cells (Hec-Ea.Hy926 Cells)

Assay & Model

In Vitro Model C57BL6 mice

In Vivo Model C57BL6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Curcumin-loaded lipid nanoemulsions (CmLN)

Subcellular Localization Cytosol

Uptake Efficiency Higher cellular internalization of R9-CmLN than of CmLN

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCSSSTTCCCTTTTC

Evidence 36 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ma-104 And Caco-2

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Fluorescein and rhodamine B dye

Subcellular Localization Cytoplasm

Uptake Mechanism Endocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCHHHHTTTSCSSTTTGGGGTSCCCSCCCCCC

Evidence 37 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, Huh-7, CHO-K1

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Carboxyfluorescein (CF)

Subcellular Localization Late Endosomes/Lysosomes

Uptake Mechanism Clathrin mediated endocytosis

In Vitro or In Vivo In vitro

Evidence 38 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, Huh-7, CHO-K1

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Carboxyfluorescein (CF)

Subcellular Localization Late Endosomes/Lysosomes

Uptake Mechanism Clathrin mediated endocytosis

In Vitro or In Vivo In vitro

Evidence 39 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa, Huh-7, CHO-K1

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Cyclic L Cationic

Source of Peptide Synthetic

Cargo Type Carboxyfluorescein (CF)

Subcellular Localization Late Endosomes/Lysosomes

Uptake Efficiency Stapled peptide showed more than 15- and 2-fold higher internalization than the R9 peptide and non-stapled

Uptake Mechanism Clathrin mediated endocytosis

In Vitro or In Vivo In vitro

Evidence 40 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Porcine Fetal Fibroblasts

Assay & Model

In Vitro Model Pig

In Vivo Model Pig

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Alexa Fluor488 labelled Cre recombinase protein

Subcellular Localization Endocytic Vesicles

Uptake Mechanism Endocytosis

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSSCCSCTTCC

Evidence 41 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa Pluc705 Cells , RAW264.7, Hepg2, And MCF-7 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type PNA705, tetramethylrhodamine (TAMRA) and GFP11 peptide

Subcellular Localization Cytoplasm

Uptake Efficiency Delivered PNA705 much better than tat and TAMRA delivery follows P17 >>P11 = P14 > P40 = Arg9 > tat = penetratin

Uptake Mechanism Direct translocation and endocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCTHHHHHHHHHSCC

Evidence 42 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Rat

In Vivo Model Rat

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

In Vitro or In Vivo In vivo

DSSP Secondary Structure CCCSSSSCC

Evidence 43 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line MDA-MB-231 Cell

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type BF2-oxasmaragdyrin

Subcellular Localization Cytoplasm

Uptake Efficiency Possesses excellent photothermal transduction efficacy

In Vitro or In Vivo In vitro

Evidence 44 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line E. Coli And M. Barkeri Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Molecular beacons and Cy5 fluorophore

Subcellular Localization Cytoplasm

Uptake Efficiency FISH-TAMB probes were successfully delivered into the cells

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSCGGGHHHHTTSSSSSCCSSSSCSSSSCCCSTTHHHHSCC

Evidence 45 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line

Caco-2 Cells Bacteroidetes (Bacteroides Vulgatus And Bacteroides Thetaiotaomicron), Firmicutes (Lactobacillus Gasseri, Latilactobacillus Sakei, And Clostridium Bolteae), Actinomicetya (Bifidobacterium Longum, And Bifidobacterium Adolescentis) , Proteobacteria (Escherichia Coli Nissle 1917 And Escherichia Coli K12) And Saccharomyces Boulardii

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type FITC-dextran

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCGGGCCCC

Evidence 46 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa pLuc705 cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type SR-A3s and SR-A5s

Subcellular Localization plasma membrane

In Vitro or In Vivo In vitro

Evidence 47 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549 cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Quantum dots (QDs)

Subcellular Localization Nucleus

Uptake Efficiency R9 has the best effect on enhancing QD delivery than QD alone

In Vitro or In Vivo In vitro

DSSP Secondary Structure CTTSSGGGGGGGGHHHHTTTTCCC

Evidence 48 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HepG2, MCF-7, MDA-MB231, HeLa cells, and L-02 hepatocytes

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Exosomes and FAM-tagged G3139-CHOlesterol (18-mer ASO)

Subcellular Localization Cytosol

Uptake Efficiency Fluorescence intensity of EXO-R9 group was about 6.03-fold higher than EXO group

Uptake Mechanism Macropinocytosis and clathrin mediated endocytosis

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCTTTSSCCSCC

Evidence 49 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A431, HEK293 and SKOV3 cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type 7D12 anti-EGFR nanobody

Uptake Efficiency Signal intensities with 7D12-Atto532

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCTTTSCCSSSCCCSCSSSCC

DSSP_Secondary_Structure

CCCCCCCCC CCCCSGGGSSCC CCCCCCCC CCCCTHHHHHHHHTTCCC CCGGGTSCC CCCSSCCCC CCSCCCCCSSCCCC CCSSCGGGHHHHSCCC CCCCCCCCCCCCC CCCSCTTSSSSCCCCCC CCSSCCCC CTTTTTCCC CCSCCSCCCSSSSCCCSTTTCSTTTSCCC CCCSCCCCCCCCSCSCHHHHHHHSCSSSCCSCCSSSSCC CCCCCC CCCSSSTTCCCTTTTC CCCHHHHTTTSCSSTTTGGGGTSCCCSCCCCCC CCSSCCSCTTCC CCCCCCCTHHHHHHHHHSCC CCCSSSSCC CCSCGGGHHHHTTSSSSSCCSSSSCSSSSCCCSTTHHHHSCC CCCCCGGGCCCC CTTSSGGGGGGGGHHHHTTTTCCC CCCCCCCTTTSSCCSCC CCTTTSCCSSSCCCSCSSSCC