TPDB

3D PDB MODEL

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TPDB ID TPDB05850

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

LRWWWIKRI

FASTA

>TPDB05850|Antibacterial|length=9
LRWWWIKRI

Formula C69H101N19O10

Absent Amino Acids ANDCEQGHMFPSTYV

Common Amino Acids W

Mass 1356.68

PI 12.41

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +3

Boman Index -4.12

Hydrophobicity -0.311

Aliphatic Index 130.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 16500

Absorbance 280nm 1216.20

Polar Residues 0

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

1

L

1

K

0

M

0

F

0

P

0

S

0

T

3

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0

Length

9

Formula

C69H101N19O10

Mass

1356.68

PI

12.41

Net Charge

+3

Boman Index

-4.12

Hydrophobicity

-0.311

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3-50 µM

Target

Target Organism Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 50 uM), E. coli ESBL (MIC 13 uM), K. pneumoniae (MIC 50 uM),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Enterobacter cloacae Strain C601

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 50 uM), E. coli ESBL (MIC 13 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13 µM

Target

Target Organism Escherichia coli ESBL

Source & Reference

Database Source NA

Other

Evidence Text

ginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 50 uM), E. coli ESBL (MIC 13 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6-63 uM), 5 E. faecalis ATC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

tant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 50 uM), E. coli ESBL (MIC 13 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6-63 uM), 5 E. faecalis ATCC29212 (MIC 6-50 uM) anti-V

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6-63 µM

Target

Target Organism Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

E. cloacae Strain C601 (MIC 50 uM), E. coli ESBL (MIC 13 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6-63 uM), 5 E. faecalis ATCC29212 (MIC 6-50 uM) anti-VRE.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6-50 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source NA

Other

Evidence Text

SBL (MIC 13 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6-63 uM), 5 E. faecalis ATCC29212 (MIC 6-50 uM) anti-VRE.