TPDB

3D PDB MODEL

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TPDB ID TPDB05823

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RKWIWRWFL

FASTA

>TPDB05823|Antibacterial|length=9
RKWIWRWFL

Formula C72H99N19O10

Absent Amino Acids ANDCEQGHMPSTYV

Common Amino Acids W

Mass 1390.70

PI 12.41

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +3

Boman Index -4.94

Hydrophobicity -0.500

Aliphatic Index 86.67

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 16500

Absorbance 280nm 1186.45

Polar Residues 0

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

1

K

0

M

1

F

0

P

0

S

0

T

3

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0

Length

9

Formula

C72H99N19O10

Mass

1390.70

PI

12.41

Net Charge

+3

Boman Index

-4.94

Hydrophobicity

-0.500

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5-12 µM

Target

Target Organism Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 1.5-12 uM), E. cloacae Strain C601 (MIC 3 uM), E. coli ESBL (MIC 1.5 uM), K. pneumoniae (MIC 3.1 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism Enterobacter cloacae Strain C601

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 1.5-12 uM), E. cloacae Strain C601 (MIC 3 uM), E. coli ESBL (MIC 1.5 uM), K. pneumoniae (MIC 3.1 uM), S. aureus ATCC 25923 or MRSA (MIC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism Escherichia coli ESBL

Source & Reference

Database Source NA

Other

Evidence Text

inosa PAO1 or WT or resistant strains (MIC 1.5-12 uM), E. cloacae Strain C601 (MIC 3 uM), E. coli ESBL (MIC 1.5 uM), K. pneumoniae (MIC 3.1 uM), S. aureus ATCC 25923 or MRSA (MIC 3-31 uM), and 5 E. faecali

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

nt strains (MIC 1.5-12 uM), E. cloacae Strain C601 (MIC 3 uM), E. coli ESBL (MIC 1.5 uM), K. pneumoniae (MIC 3.1 uM), S. aureus ATCC 25923 or MRSA (MIC 3-31 uM), and 5 E. faecalis ATCC29212 (MIC 3-24 uM) an

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3-31 µM

Target

Target Organism Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

E. cloacae Strain C601 (MIC 3 uM), E. coli ESBL (MIC 1.5 uM), K. pneumoniae (MIC 3.1 uM), S. aureus ATCC 25923 or MRSA (MIC 3-31 uM), and 5 E. faecalis ATCC29212 (MIC 3-24 uM) anti-VRE.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3-24 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source NA

Other

Evidence Text

IC 1.5 uM), K. pneumoniae (MIC 3.1 uM), S. aureus ATCC 25923 or MRSA (MIC 3-31 uM), and 5 E. faecalis ATCC29212 (MIC 3-24 uM) anti-VRE.