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Peptide record

TPDB05822

Antibacterial standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05822
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 9-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RKRLKWWIY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C67H101N19O11
ANDCEQGHMFPSTV
RKW
1348.66
11.51
4
0
5
+4
2.95
-1.289
86.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
9.26
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
9 reviewed residue count
C67H101N19O11 sequence-only estimate (linear, free termini)
1348.66 sequence-only estimate (linear, free termini)
11.51 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.95 sequence-only estimate (linear, free termini)
-1.289 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3-50 µM

Target

Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

NA

Other

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
13 µM

Target

Enterobacter cloacae Strain C601

Source & Reference

NA

Other

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ESBL

Source & Reference

NA

Other

ginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis AT
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

stant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-
Evidence 5 Activity

Activity

MIC
Antibacterial
6 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

NA

Other

, E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-VRE 2 strains MIC =>202 uM (AMP-resistant
Evidence 6 Activity

Activity

MIC
Antibacterial
3-50 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

SBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-VRE 2 strains MIC =>202 uM (AMP-resistant?).