TPDB

3D PDB MODEL

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TPDB ID TPDB05822

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

RKRLKWWIY

FASTA

>TPDB05822|Antibacterial|length=9
RKRLKWWIY

Formula C67H101N19O11

Absent Amino Acids ANDCEQGHMFPSTV

Common Amino Acids RKW

Mass 1348.66

PI 11.51

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index -1.91

Hydrophobicity -1.289

Aliphatic Index 86.67

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 12490

Absorbance 280nm 926.10

Polar Residues 1

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

2

K

0

M

0

F

0

P

0

S

0

T

2

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 1 V: 0

Length

9

Formula

C67H101N19O11

Mass

1348.66

PI

11.51

Net Charge

+4

Boman Index

-1.91

Hydrophobicity

-1.289

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3-50 µM

Target

Target Organism Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13 µM

Target

Target Organism Enterobacter cloacae Strain C601

Source & Reference

Database Source NA

Other

Evidence Text

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Escherichia coli ESBL

Source & Reference

Database Source NA

Other

Evidence Text

ginosa PAO1 or WT or resistant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis AT

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

stant strains (MIC 3-50 uM), E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

, E. cloacae Strain C601 (MIC 13 uM), E. coli ESBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-VRE 2 strains MIC =>202 uM (AMP-resistant

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3-50 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source NA

Other

Evidence Text

SBL (MIC 6 uM), K. pneumoniae (MIC 50 uM), S. aureus ATCC 25923 or MRSA (MIC 6 uM), and 5 E. faecalis ATCC29212 (MIC 3-50 uM) anti-VRE 2 strains MIC =>202 uM (AMP-resistant?).