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Peptide record

TPDB05785

Antibacterial Antifungal Hemolysis Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05785
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLKLLKKLL
Physicochemical Analysis
C57H102N12O10
ARNDCEQGHIMPSTWYV
L
1115.51
10.84
3
0
6
+3
-0.96
1.122
216.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C57H102N12O10
1115.51
10.84
+3
-0.96
1.122
Evidence Records 7 records
Evidence 1 Activity

Activity

100% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
100% Hemolysis | 125 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Feleucin-BO1: A Novel Antimicrobial Non-Apeptide Amide from the Skin Secretion of the Toad, Bombina orientalis, and Design of a Potent Broad-Spectrum Synthetic Analogue, Feleucin-K3. | Chem Biol Drug Des | 2015
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa. | Amino Acids | 2018
Evidence 3 Activity

Activity

25% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
25% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa. | Amino Acids | 2018
Evidence 4 Activity

Activity

45% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa. | Amino Acids | 2018
Evidence 5 Activity

Activity

15% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Enhancing the stability and therapeutic potential of the antimicrobial peptide Feleucin-K3 against Multidrug-Resistant a. Baumannii through rational utilization of a D-amino acid substitution strategy. | Biochem Pharmacol | 2024
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
100 %
Hemolytic
Hemolytic_activity: [Ref.25056849] 100% hemolysis at >250 mg/L against horse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2015 Mar 85(3):259-67. doi: 10.1111/cbdd.12396.
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis