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Peptide record

TPDB05774

Antibacterial Anticancer Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05774
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
LLCIALRKK
Physicochemical Analysis
C48H92N14O10S1
NDEQGHMFPSTWYV
L
1057.41
10.59
3
0
5
+3
0.39
0.878
184.44
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
3
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C48H92N14O10S1
1057.41
10.59
+3
0.39
0.878
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. h
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

st Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albica
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

E. hirae

Source & Reference

NA

Other

uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The pe
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active a
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. epidemidis

Source & Reference

NA

Other

osa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active against bacteria, even in t
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Candida albicans

Source & Reference

NA

Other

MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active against bacteria, even in the biofilms (Curr Microbiol. 2012)
Evidence 9 Activity

Activity

MIC
Antifungal
16 µM

Target

Escherichia coli

Source & Reference

CAFPdb

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. h
Evidence 10 Activity

Activity

MIC
Antifungal
16 µM

Target

Klebsiella pneumoniae

Source & Reference

CAFPdb

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus
Evidence 11 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

CAFPdb

Other

active against Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

Enterococcus faecalis

Source & Reference

CAFPdb

Other

st Gram- E. coli (MIC 16 uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albica
Evidence 13 Activity

Activity

MIC
Antifungal
4 µM

Target

E. hirae

Source & Reference

CAFPdb

Other

uM), K. pneumoniae (MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The pe
Evidence 14 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus

Source & Reference

CAFPdb

Other

MIC 16 uM), P. aeruginosa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active a
Evidence 15 Activity

Activity

MIC
Antifungal
8 µM

Target

S. epidemidis

Source & Reference

CAFPdb

Other

osa (MIC 32 uM), Gram+ E. faecalis (MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active against bacteria, even in t
Evidence 16 Activity

Activity

MIC
Antifungal
8 µM

Target

Candida albicans

Source & Reference

CAFPdb

Other

MIC 2 uM), E. hirae (MIC 4 uM), S. aureus (MIC 8 uM), S. epidemidis (MIC 8 uM), and yeast C. albicans (MIC 8 uM). The peptide is also active against bacteria, even in the biofilms (Curr Microbiol. 2012)
Evidence 17 Activity

Activity

20% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and antimicrobial activity of cysteine-free coprisin nonapeptides. | Biochem Biophys Res Commun | 2014
Evidence 18 Activity

Activity

2% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and antimicrobial activity of cysteine-free coprisin nonapeptides. | Biochem Biophys Res Commun | 2014
Evidence 19 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Microbiol Biotechnol. 2012 Jan 22(1):156-8.