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Peptide record

TPDB05762

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

9 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05762

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

KWRRWIRWL

FASTA

>TPDB05762|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=9
KWRRWIRWL

Formula C69H102N22O10

Absent Amino Acids ANDCEQGHMFPSTYV

Common Amino Acids RW

Mass 1399.71

PI 12.71

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index -3.00

Hydrophobicity -1.311

Aliphatic Index 86.67

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 16500

Absorbance 280nm 1178.82

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0

Length

Formula

C69H102N22O10

Mass

1399.71

12.71

Net Charge

Boman Index

-3.00

Hydrophobicity

-1.311

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 2

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism S. aeurus

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

li (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 2

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism S. aeurus

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

active against Gram- E. coli (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

li (MIC 6.2 ug/ml), P. aeruginosa (MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

(MIC 6.2 ug/ml), Gram+ S. aeurus (MIC 3.1 ug/ml), fungi C. albicans (MIC 3.1 ug/ml), and F. solani (MIC 25 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms. | Biochem Biophys Res Commun | 2010

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 43±16 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 43±16 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. | Int J Antimicrob Agents | 2019

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Int J Antimicrob Agents. 2019 Jun 53(6):868-872.

Evidence 14 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis