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Peptide record

TPDB05732

Antibacterial Anticancer Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05732
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia CancerPPD 2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWQWRWQWR
Physicochemical Analysis
C72H94N24O12
ANDCEGHILKMFPSTYV
W
1487.69
12.70
3
0
4
+3
-3.81
-2.678
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1478.80
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C72H94N24O12
1487.69
12.70
+3
-3.81
-2.678
Evidence Records 4 records
Evidence 1 Activity

Activity

24.8% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
24.8% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens. | Biomed Res Int | 2018
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis and Evaluation of Branched RRWQWR-Based Peptides as Antibacterial Agents Against Clinically Relevant Gram-Positive and Gram-Negative Pathogens. | Front Microbiol | 2018
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
24.8 %
Hemolytic
Hemolytic_activity: [Ref.29551999] 24.8% hemolysis at 100µM,50% hemolysis at >100µM against human red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2018 Mar 2 9:329.
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29984236] 0% haemolysis at 5 µM, 1% haemolysis at 12 µM, 0% haemolysis at 22 µM, 5% haemolysis at 50 µM, 25% haemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomed Res Int. 2018 Jun 10 2018:5252891