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Peptide record

TPDB05728

Antibacterial Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB05728
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 9-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRWWRWWRR
Physicochemical Analysis
C74H102N28O10
ANDCEQGHILKMFPSTYV
R
1543.81
13.00
5
0
4
+5
-3.35
-2.900
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1425.05
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C74H102N28O10
1543.81
13.00
+5
-3.35
-2.900
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
33.33 µM
Hemolytic Cytotoxic
5% Hemolysis | 33.33 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. | Biochim Biophys Acta | 2017
Evidence 2 Activity

Activity

50% Cell death
Toxicity
86.67 µM
Cytotoxic
50% Cell death | 86.67 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Modulating short tryptophan- and arginine-rich peptides activity by substitution with histidine. | Biochim Biophys Acta | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
86.67 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28372989] MHC5=33.33 µM against human red blood cells | Cytotoxicity: [Ref.28372989] IC50 = 86.67 µM for hPBMCs. The cell viability of hPBMCs is 98%, 96%, 89.6%, 78%, 92.8% at peptide concentrations of 0.33, 0.67, 6.67, 12.33 and 86.67 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Gen Subj. 2017 Jul 1861(7):1844-1854. doi: 10.1016/j.bbagen.2017.03.024.