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Peptide record

TPDB05662

Antibacterial standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05662
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 8-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WWLRKIWW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C68H88N16O9
ANDCEQGHMFPSTYV
W
1273.55
11.49
2
0
6
+2
0.16
-0.463
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
17.27
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8 reviewed residue count
C68H88N16O9 sequence-only estimate (linear, free termini)
1273.55 sequence-only estimate (linear, free termini)
11.49 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.16 sequence-only estimate (linear, free termini)
-0.463 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 6.2 uM), E. coli ATCC 25922 (MIC 25 uM), and K-pneumoniae ATCC 13883 (MIC >50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 6.2 uM), E. coli ATCC 25922 (MIC 25 uM), and K-pneumoniae ATCC 13883 (MIC >50 uM).