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Peptide record

TPDB05661

Antibacterial Hemolysis Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05661
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
RKIWWWWL
Physicochemical Analysis
C68H88N16O9
ANDCEQGHMFPSTYV
W
1273.55
11.49
2
0
6
+2
-6.47
-0.463
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1727.46
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H88N16O9
1273.55
11.49
+2
-6.47
-0.463
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 3.1-6.2 uM), E. coli ATCC 25922 (MIC 6.2 uM), and K. pneumoniae ATCC 13883 (MIC 3.1-6.2 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 3.1-6.2 uM), E. coli ATCC 25922 (MIC 6.2 uM), and K. pneumoniae ATCC 13883 (MIC 3.1-6.2 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 3.1-6.2 uM), E. coli ATCC 25922 (MIC 6.2 uM), and K. pneumoniae ATCC 13883 (MIC 3.1-6.2 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
57 µM
Hemolytic Cytotoxic
50% Hemolysis | 57 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis