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Peptide record

TPDB05648

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05648
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFFLSRIF
Physicochemical Analysis
C57H77N11O10
ANDCEQGHKMPTWYV
F
1076.31
11.05
1
0
6
+1
-4.45
1.775
97.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
4
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 4 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C57H77N11O10
1076.31
11.05
+1
-4.45
1.775
Evidence Records 56 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25-100 µM

Target

Escherichia coli ATCC 25922 or ML-35p or D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S.
Evidence 2 Activity

Activity

MIC
Antibacterial
>200 µM

Target

E.coli ATCC 35218

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

am- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B.
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

M), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
3 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

M), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MI
Evidence 7 Activity

Activity

MIC
Antibacterial
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromasti
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

terium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigo
Evidence 9 Activity

Activity

MIC
Antibacterial
>200 µM

Target

A.flavus

Source & Reference

dbAMP DRAMP

Other

s ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigotes (MIC >60 uM). Moderately ac
Evidence 10 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP

Other

nd L-infantumamastigotes (MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ).
Evidence 11 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.epidermidis 1457

Source & Reference

dbAMP DRAMP

Other

MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al
Evidence 12 Activity

Activity

MIC
Antibacterial
>100 µM

Target

B.subtilis 168

Source & Reference

dbAMP DRAMP

Other

t MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al., 2024 ). temporin-SHf inhibited
Evidence 13 Activity

Activity

MIC
Antifungal
25-100 µM

Target

Escherichia coli ATCC 25922 or ML-35p or D21

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S.
Evidence 14 Activity

Activity

MIC
Antifungal
>200 µM

Target

E.coli ATCC 35218

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM),
Evidence 15 Activity

Activity

MIC
Antifungal
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb

Other

am- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B.
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb

Other

M), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90
Evidence 17 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb

Other

P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC
Evidence 18 Activity

Activity

MIC
Antifungal
3 µM

Target

B. megaterium

Source & Reference

dbAMP DRAMP CAFPdb

Other

M), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MI
Evidence 19 Activity

Activity

MIC
Antifungal
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb

Other

faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromasti
Evidence 20 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb

Other

terium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigo
Evidence 21 Activity

Activity

MIC
Antifungal
>200 µM

Target

A.flavus

Source & Reference

dbAMP DRAMP CAFPdb

Other

s ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigotes (MIC >60 uM). Moderately ac
Evidence 22 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli K12

Source & Reference

dbAMP DRAMP CAFPdb

Other

nd L-infantumamastigotes (MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ).
Evidence 23 Activity

Activity

MIC
Antifungal
>100 µM

Target

S.epidermidis 1457

Source & Reference

dbAMP DRAMP CAFPdb

Other

MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al
Evidence 24 Activity

Activity

MIC
Antifungal
>100 µM

Target

B.subtilis 168

Source & Reference

dbAMP DRAMP CAFPdb

Other

t MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al., 2024 ). temporin-SHf inhibited
Evidence 25 Activity

Activity

MIC
Antiparasitic
25-100 µM

Target

Escherichia coli ATCC 25922 or ML-35p or D21

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S.
Evidence 26 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

E.coli ATCC 35218

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM),
Evidence 27 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

am- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B.
Evidence 28 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

M), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90
Evidence 29 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP

Other

P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC
Evidence 30 Activity

Activity

MIC
Antiparasitic
3 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP

Other

M), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MI
Evidence 31 Activity

Activity

MIC
Antiparasitic
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0 DRAMP

Other

faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromasti
Evidence 32 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

terium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigo
Evidence 33 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

A.flavus

Source & Reference

dbAMP 3.0 DRAMP

Other

s ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigotes (MIC >60 uM). Moderately ac
Evidence 34 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

E.coli K12

Source & Reference

dbAMP 3.0 DRAMP

Other

nd L-infantumamastigotes (MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ).
Evidence 35 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

S.epidermidis 1457

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al
Evidence 36 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

B.subtilis 168

Source & Reference

dbAMP 3.0 DRAMP

Other

t MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al., 2024 ). temporin-SHf inhibited
Evidence 37 Activity

Activity

MIC
Antiviral
25-100 µM

Target

Escherichia coli ATCC 25922 or ML-35p or D21

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S.
Evidence 38 Activity

Activity

MIC
Antiviral
>200 µM

Target

E.coli ATCC 35218

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM),
Evidence 39 Activity

Activity

MIC
Antiviral
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

am- E. coli ATCC 25922 or ML-35p or D21 (MIC 25-100 uM), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B.
Evidence 40 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

M), E.coli ATCC 35218 (MIC >200 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90
Evidence 41 Activity

Activity

MIC
Antiviral
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP

Other

P.aeruginosa ATCC 27853 (MIC >200 uM), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC
Evidence 42 Activity

Activity

MIC
Antiviral
3 µM

Target

B. megaterium

Source & Reference

dbAMP 3.0 DRAMP

Other

M), Gram-positive S. aureus ATCC 25923 (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MI
Evidence 43 Activity

Activity

MIC
Antiviral
50 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0 DRAMP

Other

faecalis ATCC 29212 (MIC 50 uM), B. megaterium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromasti
Evidence 44 Activity

Activity

MIC
Antiviral
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

terium (MIC 3 µM), yeasts C. albicans ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigo
Evidence 45 Activity

Activity

MIC
Antiviral
>200 µM

Target

A.flavus

Source & Reference

dbAMP 3.0 DRAMP

Other

s ATCC 90028, C. parapsilosis ATCC 22019 (MIC 50 uM), S. cerevisiae (MIC 12.5 uM), fungus A.flavus (MIC >200 uM), parasites L-infantumpromastigotes, and L-infantumamastigotes (MIC >60 uM). Moderately ac
Evidence 46 Activity

Activity

MIC
Antiviral
>100 µM

Target

E.coli K12

Source & Reference

dbAMP 3.0 DRAMP

Other

nd L-infantumamastigotes (MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ).
Evidence 47 Activity

Activity

MIC
Antiviral
>100 µM

Target

S.epidermidis 1457

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC >60 uM). Moderately active against MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al
Evidence 48 Activity

Activity

MIC
Antiviral
>100 µM

Target

B.subtilis 168

Source & Reference

dbAMP 3.0 DRAMP

Other

t MRSA (MIC 25 uM but not E.coli K12 (MIC >100 uM), S.epidermidis 1457 (MIC>100 uM), and B.subtilis 168 (MIC>100 uM) Mishra et al., 2017 ). Anticancer as well ( Antony et al., 2024 ). temporin-SHf inhibited
Evidence 49 Activity

Activity

LC50
Hemolysis
200 µM
[Ref.20308076] Temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 µm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3–50 µm)

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Biol Chem. 2010 May 28 285(22):16880-92.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 50 Activity

Activity

50% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
50% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide. | J Biol Chem | 2010
Evidence 51 Activity

Activity

IC50
Toxicity
157 µM
Cytotoxic
IC50 | 157 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship-based Optimization of Small Temporin-SHf Analogs with Potent Antibacterial Activity | ACS Chem Biol | 2015
Evidence 52 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship-based Optimization of Small Temporin-SHf Analogs with Potent Antibacterial Activity | ACS Chem Biol | 2015
Evidence 53 Activity

Activity

10% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
10% Hemolysis | >100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Design and evaluation of tadpole-like conformational antimicrobial peptides. | Commun Biol | 2023
Evidence 54 Activity

Activity

IC50
Toxicity
59 µM
Cytotoxic
IC50 | 59 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Design and evaluation of tadpole-like conformational antimicrobial peptides. | Commun Biol | 2023
Evidence 55 Activity

Activity

LC50
Toxicity
200 µm
Hemolytic
Hemolytic_activity: [Ref.20308076] Temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 µm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3–50 µm)

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2010 May 28 285(22):16880-92.
Evidence 56 Hemolysis

Activity

200 µM
LC50
[Ref.20308076] Temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 µm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3–50 µm)
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Biol Chem. 2010 May 28 285(22):16880-92.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.