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Peptide record

TPDB05642

Antibacterial Antifungal Toxicity standard

8 amino acids

3D PDB MODEL

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TPDB ID TPDB05642

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RIWVIWRR

FASTA

>TPDB05642|Antibacterial;Antifungal;Toxicity|length=8
RIWVIWRR

Formula C57H89N19O9

Absent Amino Acids ANDCEQGHLKMFPSTY

Common Amino Acids R

Mass 1184.46

PI 12.70

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +3

Boman Index -1.82

Hydrophobicity -0.262

Aliphatic Index 133.75

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 928.70

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1

Length

Formula

C57H89N19O9

Mass

1184.46

12.70

Net Charge

Boman Index

-1.82

Hydrophobicity

-0.262

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gainst P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis A

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albi

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

um (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

um (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb

Other

Evidence Text

C 2 uM), S. epidermidis clinical strain (MIC 4 uM), E. faecalis ATCC29212 (MIC 8 uM), and C. albicans (MIC 16 uM).

Evidence 15 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Fungicidal mechanisms of the antimicrobial peptide Bac8c. | Biochim Biophys Acta | 2015

Evidence 16 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides. | Antimicrob Agents Chemother | 2015