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Peptide record

TPDB05641

Antibacterial Antifungal Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05641
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
QPFSLERW
Physicochemical Analysis
C50H71N13O13
ANDCGHIKMTYV
REQLFPSW
1062.19
6.97
1
1
3
-0
0.45
-1.025
48.75
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5500
517.80
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C50H71N13O13
1062.19
6.97
-0
0.45
-1.025
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against active against Gram+ M. luteus A270 (MIC 47.2–94.5 uM), weakly S. aureus ATCC, S. epidermidis ATCC 1222829213 (MIC 94.5–188.9 uM), Gram- S. marcescens ATCC 4112 (MIC 23.53–47.2 uM), and weakly yeast C. albicans MDM8 (MIC 94.5–188.9 uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against active against Gram+ M. luteus A270 (MIC 47.2–94.5 uM), weakly S. aureus ATCC, S. epidermidis ATCC 1222829213 (MIC 94.5–188.9 uM), Gram- S. marcescens ATCC 4112 (MIC 23.53–47.2 uM), and weakly yeast C. albicans MDM8 (MIC 94.5–188.9 uM).
Evidence 3 Activity

Activity

<5% Hemolysis
Toxicity
188.9 µM
Hemolytic Cytotoxic
<5% Hemolysis | 188.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases | Front Immunol | 2017