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Peptide record

TPDB05640

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05640
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
WWWLRKIW
Physicochemical Analysis
C68H88N16O9
ANDCEQGHMFPSTYV
W
1273.55
11.49
2
0
6
+2
-6.47
-0.463
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1727.46
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H88N16O9
1273.55
11.49
+2
-6.47
-0.463
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.2-25 µM

Target

Escherichia coli K12 or ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 16
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP

Other

Active against E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MI
Evidence 3 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP

Other

gainst E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also activ
Evidence 4 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

B. subtilis 168

Source & Reference

dbAMP

Other

MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

lis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. glabrata

Source & Reference

dbAMP

Other

. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

dbAMP

Other

C 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
6.2-25 µM

Target

Escherichia coli K12 or ATCC 25922

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 16
Evidence 9 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP CAFPdb

Other

Active against E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MI
Evidence 10 Activity

Activity

MIC
Antifungal
6.2 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP CAFPdb

Other

gainst E. coli K12 or ATCC 25922 (MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also activ
Evidence 11 Activity

Activity

MIC
Antifungal
6.2 µM

Target

B. subtilis 168

Source & Reference

dbAMP CAFPdb

Other

MIC 6.2-25 uM), K. pneumoniae ATCC 13883 (MIC 12.5 uM), S. epidermidis 1457 (MIC 6.2 uM), B. subtilis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb

Other

lis 168 (MIC 6.2 uM), and S. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. glabrata

Source & Reference

dbAMP CAFPdb

Other

. aureus USA300 (MIC 3.1 uM MBC 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

dbAMP CAFPdb

Other

C 12.5 uM). Also active against C. albicans (MIC 12.5 uM), C. glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM).
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
50% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and surface immobilization of short anti-biofilm peptides. | Acta Biomater | 2017
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Design and surface immobilization of short anti-biofilm peptides. | Acta Biomater | 2017
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
35 µM
Hemolytic Cytotoxic
50% Hemolysis | 35 | µM | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Design and surface immobilization of short anti-biofilm peptides. | Acta Biomater | 2017
Evidence 18 Activity

Activity

50% Cell death
Toxicity
60 µM
Cytotoxic
50% Cell death | 60 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design and surface immobilization of short anti-biofilm peptides. | Acta Biomater | 2017
Evidence 19 Activity

Activity

50% Cell death
Toxicity
60 µM
Cytotoxic
50% Cell death | 60 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design and surface immobilization of short anti-biofilm peptides. | Acta Biomater | 2017
Evidence 20 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.