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Peptide record

TPDB05588

K8-anti-gyrA PNA/scPNA K8-lip Antibacterial Antifungal Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05588
K8-anti-gyrA PNA/scPNA K8-lip
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0 PerseuCPP
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
KKKKKKKK
Physicochemical Analysis
C48H98N16O9
ARNDCEQGHILMFPSTWYV
K
1043.41
11.36
8
0
0
+8
7.92
-3.900
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H98N16O9
1043.41
11.36
+8
7.92
-3.900
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bone marrow dendritic cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nanoparticle (Liposomes)
Cytosol
In vitro
CCSTTCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
K8-anti-gyrA PNA showed an antimicrobial effect against S. pyogenes M49 strain 591 with the lowest MIC at 15.6 mM. Larvae treated with K8-anti-gyrA PNA showed increased survival compared with control.
In vitro and in vivo
CCCCCC
Additional Detail Fields 1 fields
CCSTTCCC CCCCCC