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Peptide record

TPDB05555

Antibacterial Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05555
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 8-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRWWRWWR
Physicochemical Analysis
C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
-4.16
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1585.45
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N24O9
1387.62
12.88
+4
-4.16
-2.700
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.4-8 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 5.4-8 uM), S. aureus (MIC 1.8-8 uM), P. aeruginosa (MIC 3.6-8 uM), K-pneumoniae (MIC>32 uM), and A-
Evidence 2 Activity

Activity

MIC
Antibacterial
1.8-8 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. coli (MIC 5.4-8 uM), S. aureus (MIC 1.8-8 uM), P. aeruginosa (MIC 3.6-8 uM), K-pneumoniae (MIC>32 uM), and A-baumannii (MIC >32 uM) in
Evidence 3 Activity

Activity

MIC
Antibacterial
3.6-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 5.4-8 uM), S. aureus (MIC 1.8-8 uM), P. aeruginosa (MIC 3.6-8 uM), K-pneumoniae (MIC>32 uM), and A-baumannii (MIC >32 uM) in MHB (previous MICs merged with
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of short arginine- and tryptophan-rich peptides. | J Pept Sci | 2002
Evidence 5 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced Antimicrobial Screening Sensitivity Enabled the Identification of an Ultrashort Peptide KR-8 for Engineering of LL-37mini to Combat Drug-Resistant Pathogens. | ACS Infect Dis | 2023
Evidence 6 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Enhanced Antimicrobial Screening Sensitivity Enabled the Identification of an Ultrashort Peptide KR-8 for Engineering of LL-37mini to Combat Drug-Resistant Pathogens. | ACS Infect Dis | 2023