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Peptide record

TPDB05554

Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05554
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0 PerseuCPP
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
RRRRWWWW
Physicochemical Analysis
C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
-4.16
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1585.45
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N24O9
1387.62
12.88
+4
-4.16
-2.700
Evidence Records 5 records
Evidence 1 Activity

Activity

40% Cell death
Toxicity
50 µM
Cytotoxic
40% Cell death | 50 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug-resistant pathogens. | Mol Pharm | 2014
Evidence 2 Activity

Activity

45% Cell death
Toxicity
100 µM
Cytotoxic
45% Cell death | 100 | µM | target cell: Pig kidney epithelial cells PK1

Target

Pig kidney epithelial cells PK1

Source & Reference

NA
DBAASP
Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents. | Molecules | 2018
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
175 µM
Hemolytic Cytotoxic
50% Hemolysis | 175 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022
Evidence 4 Activity

Activity

<5% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
<5% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative Properties of Helical and Linear Amphipathicity of Peptides Composed of Arginine, Tryptophan, and Valine | Antibiotics (Basel) | 2024
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2022 Dec 8 65(23):15819-15839.