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Peptide record

TPDB05526

[KW]4 Antibacterial Antifungal Cell-penetrating Peptides Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB05526
[KW]4
Antibacterial Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb DRAMP dbAMP CellPPD-MOD CPPsite3.0
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KWKWKWKW
Physicochemical Analysis
C68H90N16O9
ARNDCEQGHILMFPSTYV
KW
1275.56
11.00
4
0
4
+4
-3.44
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
22000
1724.73
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N16O9
1275.56
11.00
+4
-3.44
-2.400
Free
L
Amphiphilic
Cyclic
Free
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Amphiphilic
Synthetic
FITC labelled
Cytoplasm and nucleus
Concentration-dependent internalization
In vitro
CCSSCHHHHTTTTTSHHHHHHHHTCC
Evidence 2 Activity

Activity

8% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
8% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
210 µM
Hemolytic Cytotoxic
10% Hemolysis | 210 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides. | Amino Acids | 2013
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antifungal and Antibiofilm Activities and the Mechanism of Action of Repeating Lysine-Tryptophan Peptides against Candida albicans | Microorganisms | 2020
Additional Detail Fields 1 fields
CCSSCHHHHTTTTTSHHHHHHHHTCC