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Peptide record

TPDB05524

Antibacterial Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB05524
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LNWGAILKHIIK
Physicochemical Analysis
C68H112N18O14
RDCEQMFPSTYV
I
1405.75
10.60
3
0
7
+2
-0.70
0.592
170.83
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
391.25
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
3
I
2
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C68H112N18O14
1405.75
10.60
+2
-0.70
0.592
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
It exhibited antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria (M. luteus 1.5 uM S. aureus MIC 10.6 uM E. coli, 3.7 uM P. aeruginosa 51.7 uM B. subtilis 1.3 uM), antifungal activity (C. albicans MIC 7.3 uM), and low hemolytic activity against human erythrocytes. Toxicity: Hemolytic HC50 119 uM. Updated 5/2017 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
It exhibited antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria (M. luteus 1.5 uM S. aureus MIC 10.6 uM E. coli, 3.7 uM P. aeruginosa 51.7 uM B. subtilis 1.3 uM), antifungal activity (C. albicans MIC 7.3 uM), and low hemolytic activity against human erythrocytes. Toxicity: Hemolytic HC50 119 uM. Updated 5/2017 7/2021
Evidence 3 Activity

Activity

LC50
Hemolysis
119 µM
[Ref.23483218] LC50=119µM against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Amino Acids. 2013 Jul 45(1):143-57.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
119 µM
Hemolytic Cytotoxic
50% Hemolysis | 119 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae). | Amino Acids | 2013
Evidence 5 Activity

Activity

LC50
Toxicity
119 µM
Hemolytic
Hemolytic_activity: [Ref.23483218] LC50=119µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2013 Jul 45(1):143-57.
Evidence 6 Hemolysis

Activity

119 µM
LC50
[Ref.23483218] LC50=119µM against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Amino Acids. 2013 Jul 45(1):143-57.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.