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Peptide record

TPDB05520

Ranatuerin-2 Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB05520
Ranatuerin-2
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifp Antifungipept CAFPdb i2APP ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFLDTLKGAAKDVAGKLEGLKCKITGCKLP
Physicochemical Analysis
C143H247N37O40S2
RNQHMSWY
LK
3188.88
9.59
6
3
12
+3
5.48
0.187
107.10
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.92
4
Residue Composition
number
3
A
0
R
0
N
2
D
2
C
1
E
0
Q
5
G
0
H
1
I
6
L
6
K
0
M
1
F
1
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 2 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 6 K: 6 M: 0 F: 1 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C143H247N37O40S2
3188.88
9.59
+3
5.48
0.187
Free
L
Linear
Free
Anticancer
Rana catesbeiana
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
weakly active against S. aureus (MIC 60 uM).
Evidence 2 Activity

Activity

IC50
IC50 > 128 µM
Anticancer
128 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

IC50
IC50 > 128 µM
Anticancer
128 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 4 Activity

Activity

IC50
IC50 > 128 µM
Anticancer
128 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 5 Activity

Activity

IC50
IC50 = 128 µM
Anticancer
128 µM

Target

Colon Cancer
LoVo
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 6 Activity

Activity

MIC
Antifungal
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
weakly active against S. aureus (MIC 60 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
weakly active against S. aureus (MIC 60 uM).
Evidence 8 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998
Evidence 9 Activity

Activity

IC50
Toxicity
>128 µM
Cytotoxic
IC50 | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021
Evidence 10 Activity

Activity

<10% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<10% Hemolysis | 256 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. | Int J Mol Sci | 2021
Evidence 11 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.