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Peptide record

TPDB05507

Antibacterial Anticancer Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB05507
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GLPTCGETCTLGKCNTPKCTCNWPICYKN
Physicochemical Analysis
C132H210N36O41S6
ARDQHMFSV
C
3149.70
8.02
3
1
5
+2
2.67
-0.355
40.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
233.83
15
Residue Composition
number
0
A
0
R
3
N
0
D
6
C
1
E
0
Q
3
G
0
H
1
I
2
L
3
K
0
M
0
F
3
P
0
S
5
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 3 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 3 M: 0 F: 0 P: 3 S: 0 T: 5 W: 1 Y: 1 V: 0
Chemical Descriptors
29
C132H210N36O41S6
3149.70
8.02
+2
2.67
-0.355
Evidence Records 3 records
Evidence 1 Activity

Activity

CC50
Toxicity
12.45±0.99 µM
Cytotoxic
CC50 | 12.45±0.99 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. | ACS Chem Biol | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>64 µM
Hemolytic Cytotoxic
50% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. | ACS Chem Biol | 2015
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>64µM | Cytotoxicity: HFF-1: CC50=12.45±0.99µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2015 Nov 20 10(11):2491-500.