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Peptide record

TPDB05501

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05501
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVVDILKGAAKDIAGHLASKVMNKL
Physicochemical Analysis
C113H198N32O32S1
RCEQFPTWY
AK
2549.07
10.16
5
2
13
+2
4.96
0.432
128.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
4
A
0
R
1
N
2
D
0
C
0
E
0
Q
3
G
1
H
2
I
3
L
4
K
1
M
0
F
0
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 2 L: 3 K: 4 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
25
C113H198N32O32S1
2549.07
10.16
+2
4.96
0.432
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
24.84 µM

Target

A. actinomycetemcomitans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.
Evidence 2 Activity

Activity

MIC
Antibacterial
397.45 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et a
Evidence 3 Activity

Activity

MIC
Antibacterial
109.91 µM

Target

s.aureus

Source & Reference

dbAMP DRAMP

Other

tive against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 4 Activity

Activity

MIC
Antibacterial
50.25 µM

Target

C. lusitaniae

Source & Reference

dbAMP DRAMP

Other

omitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 5 Activity

Activity

MIC
Antifungal
24.84 µM

Target

A. actinomycetemcomitans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.
Evidence 6 Activity

Activity

MIC
Antifungal
397.45 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et a
Evidence 7 Activity

Activity

MIC
Antifungal
109.91 µM

Target

s.aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tive against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 8 Activity

Activity

MIC
Antifungal
50.25 µM

Target

C. lusitaniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

omitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 9 Activity

Activity

MIC
Antiparasitic
24.84 µM

Target

A. actinomycetemcomitans

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.
Evidence 10 Activity

Activity

MIC
Antiparasitic
397.45 µM

Target

E.coli

Source & Reference

DRAMP

Other

Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et a
Evidence 11 Activity

Activity

MIC
Antiparasitic
109.91 µM

Target

s.aureus

Source & Reference

DRAMP

Other

tive against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 12 Activity

Activity

MIC
Antiparasitic
50.25 µM

Target

C. lusitaniae

Source & Reference

DRAMP

Other

omitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 13 Activity

Activity

MIC
Antiviral
24.84 µM

Target

A. actinomycetemcomitans

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.
Evidence 14 Activity

Activity

MIC
Antiviral
397.45 µM

Target

E.coli

Source & Reference

DRAMP

Other

Active against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et a
Evidence 15 Activity

Activity

MIC
Antiviral
109.91 µM

Target

s.aureus

Source & Reference

DRAMP

Other

tive against A. actinomycetemcomitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 16 Activity

Activity

MIC
Antiviral
50.25 µM

Target

C. lusitaniae

Source & Reference

DRAMP

Other

omitans (MIC 24.84 uM), E.coli (MIC 397.45 uM), Stafilococcus.aureus (MIC 109.91 uM), and C. lusitaniae (MIC 50.25 uM) ( Gusmão KAG et al., 2017 ).
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae). | Regul Pept | 2005
Evidence 18 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure - activity study of the antibacterial peptide fallaxin. | Protein Sci | 2007
Evidence 19 Activity

Activity

13% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
13% Hemolysis | 400 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Ocellatin peptides from the skin secretion of the South American frog Leptodactylus labyrinthicus (Leptodactylidae): characterization, antimicrobial activities and membrane interactions. | J Venom Anim Toxins Incl Trop Dis | 2017
Evidence 20 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic
Hemolytic_activity: [Ref:15544856]HC50>200 µM hemolytic activity of fallaxin

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2005 Jan 15 124(1-3):173-178.