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Peptide record

TPDB05493

Brevinin-1BYa Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB05493
Brevinin-1BYa
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPILASLAAKFGPKLFCLVTKKC
Physicochemical Analysis
C126H206N28O27S2
RNDEQHMWY
L
2609.31
10.17
4
0
13
+4
-2.28
1.075
122.08
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.79
4
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
5
L
4
K
0
M
3
F
2
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 4 M: 0 F: 3 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
24
C126H206N28O27S2
2609.31
10.17
+4
-2.28
1.075
Free
L
Not Available
Free
Antibacterial
Rana boylii, North America
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
17-20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
757, V3117, B51a/5 (MIC 5 uM), C. krusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
40 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

rusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

li ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B
Evidence 4 Activity

Activity

MIC
Antibacterial
>40 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP

Other

oniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

loacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. a
Evidence 6 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

, Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM T
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus NCTC 8352

Source & Reference

dbAMP DRAMP

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM Table 1, Rollins-Smith, BBA 2009 178
Evidence 8 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 9 Activity

Activity

MIC
Antifungal
17-20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
757, V3117, B51a/5 (MIC 5 uM), C. krusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MI
Evidence 10 Activity

Activity

MIC
Antifungal
40 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

rusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM),
Evidence 11 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

li ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B
Evidence 12 Activity

Activity

MIC
Antifungal
>40 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

oniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

loacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. a
Evidence 14 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM T
Evidence 15 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus NCTC 8352

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM Table 1, Rollins-Smith, BBA 2009 178
Evidence 16 Activity

Activity

MIC
Antiparasitic
17-20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
757, V3117, B51a/5 (MIC 5 uM), C. krusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MI
Evidence 17 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

DRAMP

Other

rusei ATCC 6258, V5800, 4426 (MIC 5-10 uM), also Gram- E. coli ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM),
Evidence 18 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

li ATCC 25922 (MIC 17-20 uM), K. pneumoniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B
Evidence 19 Activity

Activity

MIC
Antiparasitic
>40 µM

Target

P.mirabilis

Source & Reference

DRAMP

Other

oniae KK3 9904 (MIC 40 uM), E. cloacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM),
Evidence 20 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

loacae HNTCC 53001, P. aeruginosa ATCC 27853 (MIC 10 uM), P.mirabilis (MIC >40 uM), Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. a
Evidence 21 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

, Gram+ E. faecalis ATCC 29212 (MIC 5 uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM T
Evidence 22 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Staphylococcus aureus NCTC 8352

Source & Reference

DRAMP

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), and S. aureus NCTC 8352 (MIC 2 uM). Also active against B. dendrobatidis (MIC 12.5 uM Table 1, Rollins-Smith, BBA 2009 178
Evidence 23 Activity

Activity

HC50
Hemolysis
4 µM
[Ref.14531844]HC50=4 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Pept Res. 2003 Nov 62(5):207-213.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 24 Activity

Activity

50% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Brevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties. | Int J Antimicrob Agents | 2006
Evidence 25 Activity

Activity

HC50
Toxicity
4 µM
Hemolytic
Hemolytic_activity: [Ref.14531844]HC50=4 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 2003 Nov 62(5):207-213.
Evidence 26 Hemolysis

Activity

4 µM
HC50
[Ref.14531844]HC50=4 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Pept Res. 2003 Nov 62(5):207-213.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.