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Peptide record

TPDB05492

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05492
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SIPCGESCVFIPCTVTALLGCSCKSKVCYKN
Physicochemical Analysis
C139H229N35O42S6
RDQHMW
C
3254.92
8.02
3
1
10
+2
1.92
0.652
81.61
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1865
57.30
14
Residue Composition
number
1
A
0
R
1
N
0
D
6
C
1
E
0
Q
2
G
0
H
2
I
2
L
3
K
0
M
1
F
2
P
4
S
2
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 2 S: 4 T: 2 W: 0 Y: 1 V: 3
Chemical Descriptors
31
C139H229N35O42S6
3254.92
8.02
+2
1.92
0.652
Evidence Records 35 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.55 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S
Evidence 2 Activity

Activity

MIC
Antibacterial
13.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. lute
Evidence 3 Activity

Activity

MIC
Antibacterial
13.2 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.alb
Evidence 4 Activity

Activity

MIC
Antibacterial
5.8 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP

Other

inst Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C.
Evidence 5 Activity

Activity

MIC
Antibacterial
39 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. t
Evidence 6 Activity

Activity

MIC
Antibacterial
48 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

3.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM)
Evidence 7 Activity

Activity

MIC
Antibacterial
14.0 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP

Other

uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
56.5 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP

Other

uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
1.55 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S
Evidence 10 Activity

Activity

MIC
Antifungal
13.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. lute
Evidence 11 Activity

Activity

MIC
Antifungal
13.2 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.alb
Evidence 12 Activity

Activity

MIC
Antifungal
5.8 µM

Target

Klebsiella oxytoca

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C.
Evidence 13 Activity

Activity

MIC
Antifungal
39 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. t
Evidence 14 Activity

Activity

MIC
Antifungal
48 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

3.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM)
Evidence 15 Activity

Activity

MIC
Antifungal
14.0 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
56.5 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 17 Activity

Activity

MIC
Antiparasitic
1.55 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S
Evidence 18 Activity

Activity

MIC
Antiparasitic
13.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. lute
Evidence 19 Activity

Activity

MIC
Antiparasitic
13.2 µM

Target

P. vulgaris

Source & Reference

DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.alb
Evidence 20 Activity

Activity

MIC
Antiparasitic
5.8 µM

Target

Klebsiella oxytoca

Source & Reference

DRAMP

Other

inst Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C.
Evidence 21 Activity

Activity

MIC
Antiparasitic
39 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. t
Evidence 22 Activity

Activity

MIC
Antiparasitic
48 µM

Target

M. luteus

Source & Reference

DRAMP

Other

3.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM)
Evidence 23 Activity

Activity

MIC
Antiparasitic
14.0 µM

Target

C. kefyr

Source & Reference

DRAMP

Other

uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 24 Activity

Activity

MIC
Antiparasitic
56.5 µM

Target

C. tropicalis

Source & Reference

DRAMP

Other

uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 25 Activity

Activity

MIC
Antiviral
1.55 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S
Evidence 26 Activity

Activity

MIC
Antiviral
13.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. lute
Evidence 27 Activity

Activity

MIC
Antiviral
13.2 µM

Target

P. vulgaris

Source & Reference

DRAMP

Other

Active against Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.alb
Evidence 28 Activity

Activity

MIC
Antiviral
5.8 µM

Target

Klebsiella oxytoca

Source & Reference

DRAMP

Other

inst Gram- E. coli (MIC 1.55 uM), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C.
Evidence 29 Activity

Activity

MIC
Antiviral
39 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

), P. aeruginosa (MIC 13.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. t
Evidence 30 Activity

Activity

MIC
Antiviral
48 µM

Target

M. luteus

Source & Reference

DRAMP

Other

3.5 uM), P. vulgaris (MIC 13.2 uM), K. oxytoca (MIC 5.8 uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM)
Evidence 31 Activity

Activity

MIC
Antiviral
14.0 µM

Target

C. kefyr

Source & Reference

DRAMP

Other

uM), Gram+ S. aureus (MIC 39 uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 32 Activity

Activity

MIC
Antiviral
56.5 µM

Target

C. tropicalis

Source & Reference

DRAMP

Other

uM), M. luteus (MIC 48 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 14.0 uM), and C. tropicalis (MIC 56.5 uM).
Evidence 33 Activity

Activity

50% Hemolysis
Toxicity
405 µM
Hemolytic Cytotoxic
50% Hemolysis | 405 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. | Proc Natl Acad Sci U S A | 1999
Evidence 34 Activity

Activity

IC50
Toxicity
1850 µM
Cytotoxic
IC50 | 1850 | µM | target cell: Mouse fibroblasts

Target

Mouse fibroblasts

Source & Reference

NA
DBAASP
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. | Proc Natl Acad Sci U S A | 1999
Evidence 35 Activity

Activity

HD50
Toxicity
405 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.10430870] HD50 = 405 µM against blood type A human erythrocytes. | Cytotoxicity: [Ref.10430870] It caused 50% cell growth inhibition of mouse fibroblasts at 1850 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Proc Natl Acad Sci U S A. 1999 Aug 3 96(16):8913-8918.##J Nat Prod. 1994 Dec 57(12):1619-1625.