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Peptide record

TPDB05476

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05476
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP dbAMP 3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
C130H221N37O37S1
RCEHIFPSY
A
2926.47
10.55
4
1
15
+3
2.20
0.154
108.21
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
187.94
6
Residue Composition
number
6
A
0
R
3
N
1
D
0
C
0
E
1
Q
2
G
0
H
0
I
4
L
4
K
1
M
0
F
0
P
0
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 0 N: 3 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C130H221N37O37S1
2926.47
10.55
+3
2.20
0.154
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
40 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
40 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 10 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 13 Activity

Activity

MIC
Antiviral
10 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 14 Activity

Activity

MIC
Antiviral
40 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 15 Activity

Activity

MIC
Antiviral
2.5 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
1.3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. faecalis (MIC 10 uM), P. aeruginosa (MIC 40 uM), E. coli (MIC 2.5 uM), S. aureus (MIC 1.3 uM).
Evidence 17 Activity

Activity

Hemolysis
Hemolysis
12.5 µM
[Ref:10477123]Show some hemolytic starting at 12.5 µM against human blood

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 1999 20(6):679-686.##J Biol Chem. 2002 Dec 20 277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):336-343.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. | Peptides | 1999
Evidence 19 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:10477123]Show some hemolytic starting at 12.5 µM against human blood

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 1999 20(6):679-686.##J Biol Chem. 2002 Dec 20 277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):336-343.
Evidence 20 Hemolysis

Activity

12.5 µM
Hemolysis
[Ref:10477123]Show some hemolytic starting at 12.5 µM against human blood
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Peptides. 1999 20(6):679-686.##J Biol Chem. 2002 Dec 20 277(51):49332-49340.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):329-335.##Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov 151(3):336-343.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.