Back to search

Peptide record

TPDB05454

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05454
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPFIARLAAKVFPSIICSVTKKC
Physicochemical Analysis
C126H206N30O28S2
NDEQGHMWY
AIKF
2653.33
10.32
4
0
13
+4
-1.21
1.108
117.92
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.71
5
Residue Composition
number
3
A
1
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
3
I
2
L
3
K
0
M
3
F
2
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 3 M: 0 F: 3 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C126H206N30O28S2
2653.33
10.32
+4
-1.21
1.108
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
55 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
weakly active against S. aureus (MIC 55 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
55 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
weakly active against S. aureus (MIC 55 uM).
Evidence 3 Activity

Activity

MIC
Antiparasitic
55 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
weakly active against S. aureus (MIC 55 uM).
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 16 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides | bioRxiv | 2024
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9784389] Have no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.