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Peptide record

TPDB05452

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB05452
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifp Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
Physicochemical Analysis
C212H371N59O60S3
QHPWY
GK
4802.82
10.11
9
4
18
+5
10.30
0.204
114.35
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.60
7
Residue Composition
number
2
A
1
R
2
N
2
D
2
C
2
E
0
Q
8
G
0
H
5
I
5
L
8
K
1
M
1
F
0
P
2
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 2 E: 2 Q: 0 G: 8 H: 0 I: 5 L: 5 K: 8 M: 1 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
46
C212H371N59O60S3
4802.82
10.11
+5
10.30
0.204
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
The N-terminal 18-residue fragment showed an even broader activity spectrum. This peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
The N-terminal 18-residue fragment showed an even broader activity spectrum. This peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

The N-terminal 18-residue fragment showed an even broader activity spectrum. This peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells ( Marenah L et al., 2006 ), thereby of interest for type 2 diabetes (T2D).
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
100% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 5 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.