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Peptide record

TPDB05448

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

31 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05448

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ALWKTMLKKLGTMALHAGKAAFGAAADTISQ

FASTA

>TPDB05448|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=31
ALWKTMLKKLGTMALHAGKAAFGAAADTISQ

Formula C144H237N39O39S2

Absent Amino Acids RNCEPYV

Common Amino Acids A

Mass 3202.82

PI 10.55

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 17

Net Charge +3

Boman Index -0.04

Hydrophobicity 0.319

Aliphatic Index 88.71

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 171.72

Polar Residues 5

number

Amino Acid Distribution

A: 8 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 1 I: 1 L: 4 K: 4 M: 2 F: 1 P: 0 S: 1 T: 3 W: 1 Y: 0 V: 0

Length

Formula

C144H237N39O39S2

Mass

3202.82

10.55

Net Charge

Boman Index

-0.04

Hydrophobicity

0.319

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 38 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.7 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 38 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 38 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.7 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 38 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 38 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.7 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 38 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E-faecalis (MIC >38 uM), P. aeruginosa (MIC 38 uM), E. coli (MIC 9.7 uM), S. aureus (MIC 38 uM).

Evidence 10 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >33.0 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | >33.0 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta. | Peptides | 1999

Evidence 11 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.