Peptide record

TPDB05441

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05441
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RQRVEELSKFSKKGAAARRRK
Physicochemical Analysis
C106H189N41O29
NDCHIMPTWY
R
2501.92
12.25
9
2
6
+7
10.77
-1.638
46.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
3
A
5
R
0
N
0
D
0
C
2
E
1
Q
1
G
0
H
0
I
1
L
4
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 5 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 4 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C106H189N41O29
2501.92
12.25
+7
10.77
-1.638
Evidence Records 42 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putid
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E.
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

S. mutans

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. ty
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP DRAMP

Other

ainst Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serr
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP

Other

8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

l), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

g/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/m
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin
Evidence 9 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 10 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

ia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 11 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putid
Evidence 12 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E.
Evidence 13 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

S. mutans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. ty
Evidence 14 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serr
Evidence 15 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml),
Evidence 16 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/
Evidence 17 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

g/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/m
Evidence 18 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin
Evidence 19 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 20 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 21 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putid
Evidence 22 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E.
Evidence 23 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

S. mutans

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. ty
Evidence 24 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

ainst Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serr
Evidence 25 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

P. putida

Source & Reference

dbAMP 3.0 DRAMP

Other

8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml),
Evidence 26 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

l), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/
Evidence 27 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP

Other

g/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/m
Evidence 28 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin
Evidence 29 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 30 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

ia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 31 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putid
Evidence 32 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E.
Evidence 33 Activity

Activity

MIC
Antiviral
16 µg/mL

Target

S. mutans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. ty
Evidence 34 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ainst Gram+ B. subtilis (MIC 8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serr
Evidence 35 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

P. putida

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

8 ug/ml), S. aureus (MIC 8 ug/ml), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml),
Evidence 36 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

l), S. mutans (MIC 16 ug/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/
Evidence 37 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

g/ml), S. pneumoniae (MIC 8 ug/ml), P. putida (MIC 8 ug/ml), Gram- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/m
Evidence 38 Activity

Activity

MIC
Antiviral
16 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

- E. coli (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin
Evidence 39 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

typhimurium (MIC 8 ug/ml), Serratia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 40 Activity

Activity

MIC
Antiviral
4 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ia sp. (MIC 16 ug/ml), Fungi C. albicans (MIC 16 ug/ml), C. neoformans (MIC 8 ug/ml), and S. cerevisiae (MIC 4 ug/ml). more active than magainin 2 (MIC 12-100 ug/ml).
Evidence 41 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus. | FEBS Lett | 1997
Evidence 42 Activity

Activity

50% Cell death
Toxicity
>40.0 µM
Cytotoxic
50% Cell death | >40.0 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010