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Peptide record

TPDB05427

Antibacterial Anticancer Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB05427
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GIKEMLCNMACAQTVCKKSGGPLCDTCQAACKALG
Physicochemical Analysis
C143H248N42O46S8
RHFWY
C
3548.28
8.02
4
2
12
+2
5.02
0.269
67.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
10.57
12
Residue Composition
number
5
A
0
R
1
N
1
D
6
C
1
E
2
Q
4
G
0
H
1
I
3
L
4
K
2
M
0
F
1
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 2 G: 4 H: 0 I: 1 L: 3 K: 4 M: 2 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
35
C143H248N42O46S8
3548.28
8.02
+2
5.02
0.269
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

C. glutamicum

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against C. glutamicum (MIC 1.6 uM), B. subtilis (MIC 1.6 uM), E. coli (MIC 12.5 uM ), P. aeruginosa, A2058 (MIC 25 uM). High
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against C. glutamicum (MIC 1.6 uM), B. subtilis (MIC 1.6 uM), E. coli (MIC 12.5 uM ), P. aeruginosa, A2058 (MIC 25 uM). Highly toxic to the human mela
Evidence 3 Activity

Activity

MIC
Antifungal
1.6 µM

Target

C. glutamicum

Source & Reference

DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against C. glutamicum (MIC 1.6 uM), B. subtilis (MIC 1.6 uM), E. coli (MIC 12.5 uM ), P. aeruginosa, A2058 (MIC 25 uM). High
Evidence 4 Activity

Activity

MIC
Antifungal
1.6 µM

Target

B. subtilis

Source & Reference

DRAMP Antifungipept

Other

Active against C. glutamicum (MIC 1.6 uM), B. subtilis (MIC 1.6 uM), E. coli (MIC 12.5 uM ), P. aeruginosa, A2058 (MIC 25 uM). Highly toxic to the human mela
Evidence 5 Activity

Activity

IC50
Toxicity
7.5 µM
Cytotoxic
IC50 | 7.5 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Isolation and Characterization of Antimicrobial Peptides With Unusual Disulfide Connectivity From the Colonial Ascidian Synoicum turgens | Mar Drugs | 2020
Evidence 6 Activity

Activity

IC50
Toxicity
7.5 µM
Cytotoxic
Cytotoxicity: [Ref.31940927]Cytotoxicity: Human fibroblasts MRC-5(IC50=7.5 µM).

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Jan 12 18(1):51.