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Peptide record

TPDB05422

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB05422
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 dbACP iACP-DRLF Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSLALAALPKFLCLVFKKC
Physicochemical Analysis
C109H177N23O22S2
RNDEQGHIMTWY
L
2225.87
9.80
3
0
13
+3
-4.12
1.585
146.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.62
3
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
6
L
3
K
0
M
3
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 3 M: 0 F: 3 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C109H177N23O22S2
2225.87
9.80
+3
-4.12
1.585
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
512 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli and S. aureus (MIC 512 uM). This peptide also inhibits cancer cells H157, PC-3, U251MG, MB435S, and MCF-7.
Evidence 2 Activity

Activity

MIC
Antifungal
512 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli and S. aureus (MIC 512 uM). This peptide also inhibits cancer cells H157, PC-3, U251MG, MB435S, and MCF-7.
Evidence 3 Activity

Activity

MIC
Antiparasitic
512 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli and S. aureus (MIC 512 uM). This peptide also inhibits cancer cells H157, PC-3, U251MG, MB435S, and MCF-7.
Evidence 4 Activity

Activity

LC50
Hemolysis
5 µM
[Ref.17688900]LC50<5 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2007 Nov 50(6):746-756.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
<5 µM
Hemolytic Cytotoxic
50% Hemolysis | <5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii. | Toxicon | 2007
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
17.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 17.0 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 7 Activity

Activity

IC50
Toxicity
35.9 µM
Cytotoxic
IC50 | 35.9 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 8 Activity

Activity

LC50
Toxicity
5 µM
Hemolytic
Hemolytic_activity: [Ref.17688900]LC50<5 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2007 Nov 50(6):746-756.
Evidence 9 Hemolysis

Activity

5 µM
LC50
[Ref.17688900]LC50<5 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Toxicon. 2007 Nov 50(6):746-756.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.