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Peptide record

TPDB05421

Antibacterial Antifungal Antiparasitic Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05421
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LNLKGLIKKVASLLN
Physicochemical Analysis
C75H138N20O19
RDCEQHMFPTWY
L
1624.04
10.84
3
0
8
+3
0.74
0.640
182.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
5
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C75H138N20O19
1624.04
10.84
+3
0.74
0.640
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogene
Evidence 2 Activity

Activity

MIC
Antibacterial
30 µM

Target

Staphylococcus epidermidis clinical sample

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis A
Evidence 3 Activity

Activity

MIC
Antibacterial
15 µM

Target

M. luteus ATCC 10240

Source & Reference

dbAMP DRAMP

Other

ainst Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. co
Evidence 4 Activity

Activity

MIC
Antibacterial
15 µM

Target

Streptococcus pyogenes clinical sample

Source & Reference

dbAMP DRAMP

Other

MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis c
Evidence 5 Activity

Activity

MIC
Antibacterial
7.5 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

e (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aerug
Evidence 6 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

5 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. malto
Evidence 7 Activity

Activity

MIC
Antibacterial
60 µM

Target

P. mirabilis clinical sample

Source & Reference

dbAMP DRAMP

Other

le (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. al
Evidence 8 Activity

Activity

MIC
Antibacterial
30 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 9 Activity

Activity

MIC
Antibacterial
15 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP DRAMP

Other

C 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 10 Activity

Activity

MIC
Antibacterial
<7.5 µM

Target

Candida albicans ATCC 90112

Source & Reference

dbAMP DRAMP

Other

0 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 11 Activity

Activity

MIC
Antifungal
60 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogene
Evidence 12 Activity

Activity

MIC
Antifungal
30 µM

Target

Staphylococcus epidermidis clinical sample

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis A
Evidence 13 Activity

Activity

MIC
Antifungal
15 µM

Target

M. luteus ATCC 10240

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. co
Evidence 14 Activity

Activity

MIC
Antifungal
15 µM

Target

Streptococcus pyogenes clinical sample

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis c
Evidence 15 Activity

Activity

MIC
Antifungal
7.5 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aerug
Evidence 16 Activity

Activity

MIC
Antifungal
30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. malto
Evidence 17 Activity

Activity

MIC
Antifungal
60 µM

Target

P. mirabilis clinical sample

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

le (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. al
Evidence 18 Activity

Activity

MIC
Antifungal
30 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 19 Activity

Activity

MIC
Antifungal
15 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 20 Activity

Activity

MIC
Antifungal
<7.5 µM

Target

Candida albicans ATCC 90112

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 21 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogene
Evidence 22 Activity

Activity

MIC
Antiparasitic
30 µM

Target

Staphylococcus epidermidis clinical sample

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis A
Evidence 23 Activity

Activity

MIC
Antiparasitic
15 µM

Target

M. luteus ATCC 10240

Source & Reference

dbAMP 3.0 DRAMP

Other

ainst Gram+ S. aureus ATCC 25923 (MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. co
Evidence 24 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Streptococcus pyogenes clinical sample

Source & Reference

dbAMP 3.0 DRAMP

Other

MIC 60 uM), S. epidermidis clinical sample (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis c
Evidence 25 Activity

Activity

MIC
Antiparasitic
7.5 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP 3.0 DRAMP

Other

e (MIC 30 uM), M. luteus ATCC 10240 (MIC 15 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aerug
Evidence 26 Activity

Activity

MIC
Antiparasitic
30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

5 uM), S. pyogenes clinical sample (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. malto
Evidence 27 Activity

Activity

MIC
Antiparasitic
60 µM

Target

P. mirabilis clinical sample

Source & Reference

dbAMP 3.0 DRAMP

Other

le (MIC 15 uM), B. subtilis ATCC 6633 (MIC 7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. al
Evidence 28 Activity

Activity

MIC
Antiparasitic
30 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

7.5 uM), Gram- E. coli ATCC 25922 (MIC 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 29 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP 3.0 DRAMP

Other

C 30 uM), P. mirabilis clinical sample (MIC 60 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 30 Activity

Activity

MIC
Antiparasitic
<7.5 µM

Target

Candida albicans ATCC 90112

Source & Reference

dbAMP 3.0 DRAMP

Other

0 uM), P. aeruginosa ATCC 27853 (MIC 30 uM), S. maltophilia ATCC 13637 (MIC 15 uM), yeast C. albicans ATCC 90112 (MIC <7.5 uM),
Evidence 31 Activity

Activity

50% Hemolysis
Toxicity
530.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 530.3 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Chemical and biological characterization of four new linear cationic a-helical peptides from the venoms of two solitary eumenine wasps. | Toxicon | 2011
Evidence 32 Activity

Activity

EC50
Toxicity
530.3 µM
Hemolytic
Hemolytic_activity: [Ref.21549739]EC50=530.3 µM against mice erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2011 Jun 57(7-8):1081-1092.