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Peptide record

TPDB05419

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB05419
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFPLITSFLSKVL
Physicochemical Analysis
C83H129N15O18
ARNDCEQGHMWY
L
1625.03
10.10
1
0
9
+1
-4.03
1.750
160.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
1
K
0
M
3
F
1
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 1 M: 0 F: 3 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C83H129N15O18
1625.03
10.10
+1
-4.03
1.750
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against S. aureus or MRSA (MIC 50 uM). virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 16.79 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against S. aureus or MRSA (MIC 50 uM). virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 16.79 uM).
Evidence 3 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
active against S. aureus or MRSA (MIC 50 uM). virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 16.79 uM).
Evidence 4 Activity

Activity

MIC
Antiviral
50 µM

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
active against S. aureus or MRSA (MIC 50 uM). virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 16.79 uM).
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998
Evidence 6 Activity

Activity

50% Cell death
Toxicity
34.6 µM
Cytotoxic
50% Cell death | 34.6 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998