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Peptide record

TPDB05415

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

15 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05415

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

IIGHLIKTALGMLGL

FASTA

>TPDB05415|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=15
IIGHLIKTALGMLGL

Formula C72H128N18O17S1

Absent Amino Acids RNDCEQFPSWYV

Common Amino Acids L

Mass 1549.98

PI 10.10

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -1.45

Hydrophobicity 1.560

Aliphatic Index 188.67

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 3 L: 4 K: 1 M: 1 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C72H128N18O17S1

Mass

1549.98

10.10

Net Charge

Boman Index

-1.45

Hydrophobicity

1.560

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aur

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 12 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 u

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 uM), S. epidermidis ATCC14

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism M. luteus ATCC9341

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

M), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 uM), S. epidermidis ATCC14990 (IC50 25 uM), S. uberis (IC50

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 12 µM

Target

Target Organism Staphylococcus aureus ATCC29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

00 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 uM), S. epidermidis ATCC14990 (IC50 25 uM), S. uberis (IC50 25 uM), Gram- E.cloacae ATCC13047

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Staphylococcus epidermidis ATCC14990

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 uM), S. epidermidis ATCC14990 (IC50 25 uM), S. uberis (IC50 25 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

41 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 uM), S. epidermidis ATCC14990 (IC50 25 uM), S. uberis (IC50 25 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updaate

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M.

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aur

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 12 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 u

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism M. luteus ATCC9341

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 12 µM

Target

Target Organism Staphylococcus aureus ATCC29213

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Staphylococcus epidermidis ATCC14990

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism B. cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M.

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aur

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 12 µM

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 u

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism L. innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism M. luteus ATCC9341

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 12 µM

Target

Target Organism Staphylococcus aureus ATCC29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Staphylococcus epidermidis ATCC14990

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism B. cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M.

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aur

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 12 µM

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ B. cereus (IC50 25 uM), E. faecalis ATCC29212 (IC50 100 uM), L. lactis (IC50 12 uM), L. innocua (IC50 50 uM), M. luteus ATCC9341 (IC50 25 uM), S. aureus ATCC29213 (IC50 12 u

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism L. innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism M. luteus ATCC9341

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 12 µM

Target

Target Organism Staphylococcus aureus ATCC29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Staphylococcus epidermidis ATCC14990

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text