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Peptide record

TPDB05413

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB05413
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 50-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KDRPKKPGLCPPRPQKPCVKECKNDDSCPGQQKCCNYGCKDECRDPIFVG
Physicochemical Analysis
C234H380N72O72S8
AHMTW
CKP
5610.51
8.31
11
7
6
+4
22.17
-1.274
27.20
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1990
35.47
15
Residue Composition
number
0
A
3
R
2
N
5
D
8
C
2
E
3
Q
4
G
0
H
1
I
1
L
8
K
0
M
1
F
8
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 5 C: 8 E: 2 Q: 3 G: 4 H: 0 I: 1 L: 1 K: 8 M: 0 F: 1 P: 8 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
50
C234H380N72O72S8
5610.51
8.31
+4
22.17
-1.274
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
It contains a (whey acidic domain) WAP domain, which is known to be antimicrobial. Diffusion assay: Active against Gram+ B. megaterium, S. warneri, but not B.thuringiensis, S. aureus and S.clavuligerus even at 5.6 mg/ml (2.8 mM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
It contains a (whey acidic domain) WAP domain, which is known to be antimicrobial. Diffusion assay: Active against Gram+ B. megaterium, S. warneri, but not B.thuringiensis, S. aureus and S.clavuligerus even at 5.6 mg/ml (2.8 mM).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

It contains a (whey acidic domain) WAP domain, which is known to be antimicrobial. Diffusion assay: Active against Gram+ B. megaterium, S. warneri, but not B.thuringiensis, S. aureus and S.clavuligerus even at 5.6 mg/ml (2.8 mM).
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins. | Biochem J | 2007