TPDB

3D PDB MODEL

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TPDB ID TPDB05409

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

GWASKIGQTLGKMAKVGLQELIQPK

FASTA

>TPDB05409|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=25
GWASKIGQTLGKMAKVGLQELIQPK

Formula C121H205N33O33S1

Absent Amino Acids RNDCHFY

Common Amino Acids GK

Mass 2682.22

PI 10.55

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +3

Boman Index 3.83

Hydrophobicity -0.204

Aliphatic Index 97.60

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 205.05

Polar Residues 5

number

2

A

0

R

0

N

0

D

0

C

1

E

3

Q

4

G

0

H

2

I

3

L

4

K

1

M

0

F

1

P

1

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 3 G: 4 H: 0 I: 2 L: 3 K: 4 M: 1 F: 0 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 1

Length

25

Formula

C121H205N33O33S1

Mass

2682.22

PI

10.55

Net Charge

+3

Boman Index

3.83

Hydrophobicity

-0.204

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 50 uM).