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Peptide record

TPDB05408

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB05408
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SLLSLIRKLIT
Physicochemical Analysis
C58H109N15O15
ANDCEQGHMFPWYV
L
1256.59
11.49
2
0
6
+2
-0.66
1.227
212.73
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
1
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C58H109N15O15
1256.59
11.49
+2
-0.66
1.227
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
80 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
. saprophyticus, B. subtilis CCT 2471, B. thuringiensis (MIC all at 40 uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. al
Evidence 2 Activity

Activity

MIC
Antibacterial
40 µM

Target

Alcaligenes faecalis ATCC 8750

Source & Reference

dbAMP DRAMP

Other

uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. albicans (40 uM). It only showed weak leishmanicidal activity IC50=72 uM (c
Evidence 3 Activity

Activity

MIC
Antifungal
80 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
. saprophyticus, B. subtilis CCT 2471, B. thuringiensis (MIC all at 40 uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. al
Evidence 4 Activity

Activity

MIC
Antifungal
40 µM

Target

Alcaligenes faecalis ATCC 8750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. albicans (40 uM). It only showed weak leishmanicidal activity IC50=72 uM (c
Evidence 5 Activity

Activity

MIC
Antiparasitic
80 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
. saprophyticus, B. subtilis CCT 2471, B. thuringiensis (MIC all at 40 uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. al
Evidence 6 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Alcaligenes faecalis ATCC 8750

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), Gram-negative E. coli ATCC 25922 (MIC 80 uM), K. pneumoniae ATCC 13883 (80 uM), and A. faecalis ATCC 8750 (MIC 40 uM), and yeast C. albicans (40 uM). It only showed weak leishmanicidal activity IC50=72 uM (c
Evidence 7 Activity

Activity

EC50
Hemolysis
1 mM
[Ref.17981364]EC50=1 mM against mouse erythrocytes

Target

mouse erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2007 Dec 28(12):2320-2327.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
50% Hemolysis | 1000 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. | Peptides | 2007
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. | Peptides | 2007
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
50% Hemolysis | 300 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. | Peptides | 2007
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
50% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus. | Peptides | 2007
Evidence 12 Activity

Activity

0% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
0% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of leucine-substituted decoralin analogs with lower hemolytic activity. | J Pept Sci | 2017
Evidence 13 Activity

Activity

50% Cell death
Toxicity
100 µM
Cytotoxic
50% Cell death | 100 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Natural and redesigned wasp venom peptides with selective antitumoral activity. | Beilstein J Org Chem | 2018
Evidence 14 Activity

Activity

EC50
Toxicity
1 mM
Hemolytic
Hemolytic_activity: [Ref.17981364]EC50=1 mM against mouse erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2007 Dec 28(12):2320-2327.
Evidence 15 Hemolysis

Activity

1 mM
EC50
[Ref.17981364]EC50=1 mM against mouse erythrocytes
Hemolysis

Target

mouse erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2007 Dec 28(12):2320-2327.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.