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Peptide record

TPDB05404

Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB05404
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept i2APP HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FHPSLWVLIPQYIQLIRKILKSG
Physicochemical Analysis
C134H213N33O29
ANDCEMT
IL
2750.37
10.72
4
0
12
+3
-1.25
0.448
148.26
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
254.15
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
1
G
1
H
4
I
4
L
2
K
0
M
1
F
2
P
2
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 4 L: 4 K: 2 M: 0 F: 1 P: 2 S: 2 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
23
C134H213N33O29
2750.37
10.72
+3
-1.25
0.448
Evidence Records 10 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
95 %
[Ref.17927208]95% hemolytic activity at 25 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochemistry. 2007 Nov 6 46(44):12586-12593.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

40% Hemolysis
Toxicity
1 µM
Hemolytic Cytotoxic
40% Hemolysis | 1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conolysin-Mt: a conus peptide that disrupts cellular membranes | Biochemistry | 2007
Evidence 3 Activity

Activity

90% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
90% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conolysin-Mt: a conus peptide that disrupts cellular membranes | Biochemistry | 2007
Evidence 4 Activity

Activity

IC50
Toxicity
2.85±0.29 µM
Cytotoxic
IC50 | 2.85±0.29 | µM | target cell: Human pancreas epithelial cells HPNE

Target

Human pancreas epithelial cells HPNE

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 5 Activity

Activity

IC50
Toxicity
1.32±0.06 µM
Cytotoxic
IC50 | 1.32±0.06 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 6 Activity

Activity

IC50
Toxicity
4.70±0.20 µM
Cytotoxic
IC50 | 4.70±0.20 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 7 Activity

Activity

IC50
Toxicity
7.29±0.69 µM
Cytotoxic
IC50 | 7.29±0.69 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of anticancer peptides from natural and generated sequences using deep learning. | Int J Biol Macromol | 2025
Evidence 9 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.17927208]95% hemolytic activity at 25 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochemistry. 2007 Nov 6 46(44):12586-12593.
Evidence 10 Hemolysis

Activity

95 %
% Hemolysis
[Ref.17927208]95% hemolytic activity at 25 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Biochemistry. 2007 Nov 6 46(44):12586-12593.
DRAMP4
PD_Hemolysis